1-[4-(4-Methoxyphenyl)piperazin-1-yl]-3-(2,6-dioxopiperidin-1-yl)propane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[4-(4-Methoxyphenyl)piperazin-1-yl]-3-(2,6-dioxopiperidin-1-yl)propane
• 英文别名: 1-[3-[4-(4-Methoxyphenyl)piperazin-1-yl]propyl]piperidine-2,6-dione
• 化学式: C₁₉H₂₇N₃O₃
• 分子量: 345.442
• InChiKey: HZVNVCCVPVFNHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  53.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS
  申请人：RANBAXY LABORATORIES, LTD.

  公开号：EP1097134A1

  公开（公告）日：2001-05-09
• US6083950A
  申请人：——

  公开号：US6083950A

  公开（公告）日：2000-07-04
• US6410735B1
  申请人：——

  公开号：US6410735B1

  公开（公告）日：2002-06-25
• [EN] ARYLPIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVE ALPHA-1-ADRENOCEPTOR BLOCKERS<br/>[FR] DERIVES D'ARYLPIPERAZINE UTILES COMME AGENTS BLOQUANTS DE RECEPTEURS ALPHA 1-ADRENERGIQUES UROSELECTIFS
  申请人：RANBAXY LAB LTD

  公开号：WO2000005206A1

  公开（公告）日：2000-02-03

  Compounds of formula (I) have been found to exhibit selective alpha A1 adrenergic activity. The compounds are useful for treatment of disease conditions, such as peripheral vascular disease, congestive heart failure, hypertension and especially benign prostatic hypertrophy.
• [EN] ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS<br/>[FR] DERIVES D'ARYLPIPERAZINE UTILISES COMME AGENTS BLOQUANTS LES RECEPTEURS ALPHA1-ADRENERGIQUES UROSELECTIFS
  申请人：RANBAXY LAB LTD

  公开号：WO2000005205A1

  公开（公告）日：2000-02-03

  Novel piperazine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6-dioxopiperidin-1-yl) alkanes have been found to exhibit selective α1A adrenergic activity. The compounds are useful for treatment of disease conditions, such as peripheral vascular disease, congestive heart failure, hypertension and especially benign prostatic hypertrophy.