7-(Benzenesulfonyl)-2-methyl-4-piperazin-1-ylquinoline;hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 7-(Benzenesulfonyl)-2-methyl-4-piperazin-1-ylquinoline;hydrochloride
• 化学式: C20H22ClN3O2S
• 分子量: 403.9
• InChiKey: NBXNIDZSZCJUJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.21
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel compounds
  申请人：Johnson Norbert Christopher

  公开号：US20050124626A1

  公开（公告）日：2005-06-09

  The present invention relates to novel quinoline and aza indole compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.

  本发明涉及具有药理活性的新奎诺啉和氮杂吲哌化合物，其制备过程，包含它们的组合物以及它们在治疗中枢神经系统和其他疾病中的应用。
• QUINOLINE AND AZA-INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1497291A2

  公开（公告）日：2005-01-19
• [EN] NOVEL COMPOUNDS<br/>[FR] COMPOSES
  申请人：GLAXO GROUP LTD

  公开号：WO2003080608A2

  公开（公告）日：2003-10-02

  The present invention relates to quinoline and aza indole compounds of formula (I) or a pharmaceutically acceptable salt thereof having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.