(2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyrimidin-2-yl-piperazin-1-yl)-propyl]-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyrimidin-2-yl-piperazin-1-yl)-propyl]-amine
• 英文别名: N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]-4H-1,4-benzoxazin-3-imine
• 化学式: C₁₉H₂₄N₆O
• 分子量: 352.439
• InChiKey: GFVIYFMYUBERQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  65.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2H-1,4-苯并噁嗪-3(4H)-酮 以 氯仿 为溶剂， 生成 (2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyrimidin-2-yl-piperazin-1-yl)-propyl]-amine
  参考文献：
  名称：

  A new series of selective dopamine D4 ligands: 3-([4-arylpiperazin-1-yl]alkylamino)-2H-1,4-benzoxazines

  摘要：

  A series of 3-[(4-arylpiperaz-1-yl)alkylamino]-2H-1,4-benzoxazines were prepared and their affinities for cloned human D-2, D-3, and D-4 dopamine receptor subtypes were measured. This led to the identification of 1a, 1f, and 1g as high affinity selective antagonists at the D-4 receptor. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00442-3

文献信息

• A new series of selective dopamine D4 ligands: 3-([4-arylpiperazin-1-yl]alkylamino)-2H-1,4-benzoxazines
  作者：Xiao Shu He、Kristine Woodruff、Robbin Brodbeck

  DOI：10.1016/s0960-894x(97)00442-3

  日期：1997.9

  A series of 3-[(4-arylpiperaz-1-yl)alkylamino]-2H-1,4-benzoxazines were prepared and their affinities for cloned human D-2, D-3, and D-4 dopamine receptor subtypes were measured. This led to the identification of 1a, 1f, and 1g as high affinity selective antagonists at the D-4 receptor. (C) 1997 Elsevier Science Ltd.