4-[2-[4-(3-Methylphenyl)piperazin-1-yl]ethyl]-2-pyridin-4-yl-1,3-thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[2-[4-(3-Methylphenyl)piperazin-1-yl]ethyl]-2-pyridin-4-yl-1,3-thiazole
• 化学式: C₂₁H₂₄N₄S
• 分子量: 364.5
• InChiKey: NJMPBMAELDLDRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] THIAZOLE DERIVATIVES AND THEIR USE D2- AND 5-HT1A-RECEPTOR LIGANDS<br/>[FR] DERIVES DE THIAZOLES ET LEUR UTILISATION COMME LIGANDS DU RECEPTEUR D2- ET 5-HT1A
  申请人：MERCK PATENT GMBH

  公开号：WO2003074518A1

  公开（公告）日：2003-09-12

  The invention relates to thiazole derivatives of the Formula (I): in which X has the meaning as indicated in claim 1, their preparation and their use as psychopharmaceuticals and/or as active compounds of medicaments for the treatment and/or prophylaxis of movement disorders and/or for the manufacture of a medicament for the treatment of adverse effects of anti-Parkinsonian drugs in extrapyramidal movement disorders and/or for the manufacture of a medicament for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.