N-(3,5-dichloropyridin-4-yl)-7-(difluoromethoxy)-2-propan-2-yl-1-benzofuran-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: N-(3,5-dichloropyridin-4-yl)-7-(difluoromethoxy)-2-propan-2-yl-1-benzofuran-4-carboxamide
• 化学式: C₁₈H₁₄Cl₂F₂N₂O₃
• 分子量: 415.2
• InChiKey: UERMLJIAWPTMQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist
  申请人：Nycomed GmbH

  公开号：EP1849468A2

  公开（公告）日：2007-10-31

  The invention relates to the combined administration of PDE4 or PDE3/4 inhibitors and histamine receptor antagonists for the treatment of respiratory diseases.

  本发明涉及联合使用 PDE4 或 PDE3/4 抑制剂和组胺受体拮抗剂治疗呼吸系统疾病。
• Synergistic combination
  申请人：Nycomed GmbH

  公开号：EP2193808A1

  公开（公告）日：2010-06-09

  The invention relates to the combined administration of PDE inhibitors and β2 adrenoceptor agonists for the treatment of respiratory tract disorders.

  本发明涉及联合使用 PDE 抑制剂和 β2 肾上腺素受体激动剂治疗呼吸道疾病。
• NOVEL BENZOFURAN-4-CARBOXAMIDES
  申请人：Byk Gulden Lomberg Chemische Fabrik GmbH

  公开号：EP0923568A1

  公开（公告）日：1999-06-23
• US6211203B1
  申请人：——

  公开号：US6211203B1

  公开（公告）日：2001-04-03
• [EN] NOVEL BENZOFURAN-4-CARBOXAMIDES<br/>[FR] NOUVEAUX BENZOFURAN-4-CARBOXAMIDES
  申请人：——

  公开号：WO1998007715A1

  公开（公告）日：1998-02-26

  [EN] Compounds of formula (I) in which R1 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine, R2 is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, Ar is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where R3 is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino, R4 is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy, R5 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy, R6 is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino, R7 is hydrogen, halogen, amino or 1-4C-alkyl, R8 is hydrogen or halogen and R9 is hydrogen or halogen, the salts of this compound, and the N-oxides of the pyridines and their salts are active bronchial therapeutics.
  [FR] Les composés de la formule (I) où R1 est 1-2C-alkoxy ou 1-2C-alkoxy, qui est entièrement or principalement substitué par la fluorine, R2 est 1-7C-alkyle, 3-7C-cycloalkyle ou 3-7C-cycloalkylméthyle, Ar est phényle, pyridyle, phényle qui est substitué R3, R4 et R5 ou pyridyle qui est substitué par R6, R7, R8 et R9, où est R3 est hydroxyle, halogène, cyano, carboxyle, trifluorométhyle, 1-4C-alkyle, 1-4C-alkoxy, 1-4C-alkoxycarbonyle, 1-4C-alkylcarbonyle, 1-4C-Alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino ou 1-4C-alkylcarbonylamino, R4 est hydrogène, hydroxyle, halogène, amino, trifluorométhyle, 1-4C-alkyle ou 1-4C-alkoxy, R5 is hydrogène, halogène, 1-4C-alkyle or 1-4C-alkoxy, R6 is hydroxyle, halogène, cyano, carboxyle, 1-4C-alkyle, 1-4C-alkoxy, 1-4C-alkoxycarbonyle ou amino, R7 est hydrogène, halogène, amino ou 1-4C-alkyle, R8 est hydrogène ou halogène et R9 is hydrogène ou halogène, les sels de ce composé, les N-oxydes des pyridines et leurs sels sont des produits à action thérapeutique sur les bronches.