1-(1-Benzothiophen-3-yl)-3-(4-quinolin-8-ylpiperazin-1-yl)propan-1-ol;hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(1-Benzothiophen-3-yl)-3-(4-quinolin-8-ylpiperazin-1-yl)propan-1-ol;hydrochloride
• 化学式: C24H26ClN3OS
• 分子量: 440.0
• InChiKey: NFRWHKWIVZZPOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.12
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Benzothiophene derivative compounds process of preparation and use thereof
  申请人：——

  公开号：US20040034219A1

  公开（公告）日：2004-02-19

  This invention provides new benzothiophene derivatives of general formula (I) and a process for preparing them, the corresponding compositions and their use for manufacturing a medicine for the treatment of neurological disorders. These new compounds behave as serotonin reuptake inhibitors and show high affinity towards the 5-HT 1A receptor.

  本发明提供了一种新的苯并噻吩衍生物通式（I）及其制备方法、相应的组合物以及它们用于制造治疗神经系统疾病的药物。这些新化合物具有作为5-HT1A受体的血清素再摄取抑制剂的行为，并表现出高亲和力。
• BENZOTHIOPHENE DERIVATIVE COMPOUNDS, PROCESS OF PREPARATION AND USE THEREOF
  申请人：LABORATORIOS VITA, S.A.

  公开号：EP1337528B1

  公开（公告）日：2004-08-04
• [EN] BENZOTHIOPHENE DERIVATIVE COMPOUNDS, PROCESS OF PREPARATION AND USE THEREOF<br/>[FR] COMPOSES DERIVES DE BENZOTHIOPHENE, LEUR PROCEDE DE PREPARATION ET D'UTILISATION
  申请人：VITA INVEST SA

  公开号：WO2002044170A2

  公开（公告）日：2002-06-06

  This invention provides new benzothiophene derivatives of general formula (I) and a process for preparing them, the corresponding compositions and their use for manufacturing a medicine for the treatment of neurological disorders. These new compounds behave as serotonin reuptake inhibitors and show high affinity towards the 5-HT1A receptor.