6-Methyl-5-[4-(4-methylsulfonylphenyl)piperazin-1-yl]pyrimidine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-Methyl-5-[4-(4-methylsulfonylphenyl)piperazin-1-yl]pyrimidine-2,4-diamine
• 化学式: C₁₆H₂₂N₆O₂S
• 分子量: 362.5
• InChiKey: FGIOEMDQLFNGNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Diaminopyrimidines and combination therapies effective for treatment of P-glycoprotein positive cancers
  申请人：——

  公开号：US20040006042A1

  公开（公告）日：2004-01-08

  The present invention provides compounds of Formula II: 1

  本发明提供了II式化合物：1
• Diaminopyrimidines and their production
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0103464A2

  公开（公告）日：1984-03-21

  Substituted-phenyl derivatives of 5-(1,4-piperazinyl)-2,4--pyrimidinediamine are effective as antibacterial and antitumor agents. Processes for preparing such compounds, pharmaceutical compositions based thereon, and the treatment of bacterial infections in a mammal are disclosed.

  5-(1,4-哌嗪基)-2,4-嘧啶二胺的取代苯基衍生物是有效的抗菌剂和抗肿瘤剂。本文公开了制备此类化合物的工艺、基于此类化合物的药物组合物以及哺乳动物细菌感染的治疗方法。
• Leukotriene antagonists, their production and use and compositions containing them
  申请人：MERCK FROSST CANADA INC.

  公开号：EP0123543B1

  公开（公告）日：1988-02-03
• US4532240A
  申请人：——

  公开号：US4532240A

  公开（公告）日：1985-07-30
• [EN] DIAMINOPYRIMIDINES AND COMBINATION THERAPIES EFFECTIVE FOR TREATMENT OF P-GLYCOPROTEIN POSITIVE CANCERS<br/>[FR] DIAMINOPYRIMIDINES ET POLYTHERAPIES POUR TRAITER EFFICACEMENT LES CANCERS POSITIFS POUR LA GLYCOPROTEINE P
  申请人：WARNER LAMBERT CO

  公开号：WO2000009131A1

  公开（公告）日：2000-02-24

  The present invention provides compounds of Formula (II). Also provided is a method of treating cancer using a combination of 5-fluorouracil, leucovorin, and a compound of Formula (I) or (II); or a combination of a thymidylate synthase inhibitor as a compound of Formula (I) or (II).