N-[3-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]phenyl]methanesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-[3-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]phenyl]methanesulfonamide
• 化学式: C₂₀H₂₄F₃N₃O₂S
• 分子量: 427.5
• InChiKey: UBIKVSZZFMTOKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine and pharmaceutically acceptable salts and solvents thereof
  申请人：——

  公开号：US20040067962A1

  公开（公告）日：2004-04-08

  The present invention provides a compound of the formula (I), and the pharmaceutically acceptable salts and solvates thereof, which is useful for treating bladder over-activity or urinary incontinence.

  本发明提供了一种符合式(I)的化合物，以及其药用可接受的盐和溶剂合物，用于治疗膀胱过度活动或尿失禁。
• 1-(2-M-METHANESULFONAMIDOPHENYLETHYL)-4-(M-TRIFLUOROMETHYLPHENYL)PIPERAZINE AND PHARMACEUTICALLY ACCEPTABLE SALTS AND SOLVATES THEREOF AND THEIR USE IN THE TREATEMENT OF INCONTINENCE
  申请人：ELI LILLY AND COMPANY

  公开号：EP1341777A2

  公开（公告）日：2003-09-10
• US6864262B2
  申请人：——

  公开号：US6864262B2

  公开（公告）日：2005-03-08
• [EN] 1-(2-m-METHANESULFONAMIDOPHENYLETHYL)-4-(m-TRIFLUOROMETHYLPHENYL)PIPERAZINE AND PHARMACEUTICALLY ACCEPTABLE SALTS AND SOLVENTS THEREOF<br/>[FR] 1-(2-M-METHANESULFONAMIDOPHENYLETHYL)-4-(M-TRIFLUOROMETHYLPHENYL) PIPERAZINE, SES SELS ACCEPTABLES SUR LE PLAN PHARMACEUTIQUE ET SES SOLVANTS
  申请人：LILLY CO ELI

  公开号：WO2002044159A2

  公开（公告）日：2002-06-06

  The present invention provides a compound of the formula (I), and the pharmaceutically acceptable salts and solvates thereof, which is useful for treating bladder over-activity or urinary incontinence.
• [EN] 1-(2-M-METHANESULFONAMIDOPHENYLETHYL)-4-(M-TRIFLUOROMETHYLPHENYL)PIPERAZINE AND PHARMACEUTICALLY ACCEPTABLE SALTS AND SOLVATES THEREOF AND THEIR USE IN THE TREATMENT OF INCONTINENCE<br/>[FR] 1-(2-M-METHANESULFONAMIDOPHENYLETHYL)-4-(M-TRIFLUOROMETHYLPHENYL) PIPERAZINE, SES SELS ACCEPTABLES SUR LE PLAN PHARMACEUTIQUE ET SES SOLVANTS
  申请人：——

  公开号：WO2002044159A3

  公开（公告）日：2002-08-22

  [EN] The present invention provides a compound of the formula (I), and the pharmaceutically acceptable salts and solvates thereof, which is useful for treating bladder over-activity or urinary incontinence.
  [FR] L'invention concerne un composé représenté par la formule (I), ses sels acceptables sur le plan pharmaceutique et ses solvates utiles pour traiter la suractivité de la vessie ou l'incontinence urinaire.