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4-[4-[4-[4-[[(2R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-2-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

中文名称
——
中文别名
——
英文名称
4-[4-[4-[4-[[(2R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-2-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
英文别名
——
4-[4-[4-[4-[[(2R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-2-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one化学式
CAS
——
化学式
C37H42F2N8O4
mdl
——
分子量
700.8
InChiKey
IEAWASLYDSYMSP-GGJDKBGWSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.8
  • 重原子数:
    51
  • 可旋转键数:
    12
  • 环数:
    7.0
  • sp3杂化的碳原子比例:
    0.41
  • 拓扑面积:
    112
  • 氢给体数:
    1
  • 氢受体数:
    11

文献信息

  • [EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
    申请人:GILEAD APOLLO LLC
    公开号:WO2017075056A1
    公开(公告)日:2017-05-04
    The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
    本发明提供了化合物I和II,这些化合物可用作乙酰辅酶A羧化酶(ACC)的抑制剂,以及它们的组合物和使用方法。
  • PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY
    申请人:Rewcastle Gordon William
    公开号:US20110009405A1
    公开(公告)日:2011-01-13
    Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazoles of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.
    本文提供了式I的嘧啶基和1,3,5-三嗪基苯并咪唑化合物,以及它们的药物组合物、制备方法,以及作为抗癌治疗药物或药剂的用途,可以单独使用,也可以与放疗和/或其他抗癌药物联合使用。
  • [EN] PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS<br/>[FR] DÉRIVÉS DE PYRROLOTRIAZINONE EN TANT QU'INHIBITEURS DES PI3K
    申请人:ALMIRALL SA
    公开号:WO2014060432A1
    公开(公告)日:2014-04-24
    New pyrrolotriazinone derivatives having the chemical structure of formula (I), are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks)
    新的吡咯三唑酮衍生物具有化学结构式(I),公开;以及它们的制备方法,包括它们的药物组合物和它们作为磷脂酰肌醇3-激酶(PI3Ks)抑制剂在治疗中的应用。
  • [EN] NOVEL AGENTS TARGETING CYP51<br/>[FR] NOUVEAUX AGENTS CIBLANT CYP51
    申请人:SCRIPPS RESEARCH INST
    公开号:WO2015048306A1
    公开(公告)日:2015-04-02
    The invention provides inhibitors of a sterol C14-demethylase, a new series of 4- aminopyridyl-based lead inhibitors targeting Trypanosoma cruzi CYP51 (TcCYP51) developed using structure-based drug design as well as structure -property relationship (SPR) analyses. The screening hit starting point, LP 10 (KD < 42 nM; EC50 of 0.65 μΜ), has been optimized to give the potential leads that have low nanomolar binding affinity to TcCYP51 and significant activity against T. cruzi amastigotes cultured in human myoblasts. Many of the optimized compounds have improved microsome stability, and most are selective against the T. cruzi CYP51 relative to human CYPs 1A2, 2D6 and 3A4 (<50% inhibition at 1 μΜ). A rationale for the improvement of microsome stability and selectivity of inhibitors against human metabolic CYP enzymes is presented. In addition, the binding mode of several compounds of the invention with the T. brucei CYP51 (TbCYP51) ortholog has been characterized by x-ray structure analysis. Orally active compounds and their cyclodextrin complexes have been shown to be effective against Chagas-infected mice.
    该发明提供了一种甾醇C14-去甲基酶的抑制剂,这是一种新系列基于4-氨基吡啶的首选抑制剂,通过基于结构的药物设计以及结构-性质关系(SPR)分析来瞄准Trypanosoma cruzi CYP51(TcCYP51)而开发的。筛选起始点LP 10(KD < 42 nM;EC50为0.65 μΜ)已经经过优化,产生了具有低纳摩尔级别结合亲和力和对在人类肌细胞培养的T. cruzi游离体的显著活性的潜在首选抑制剂。许多经过优化的化合物具有改善的微粒体稳定性,大多数相对于人类CYPs 1A2、2D6和3A4对T. cruzi CYP51具有选择性(在1 μΜ下<50%的抑制)。提出了改善微粒体稳定性和抑制剂对人类代谢CYP酶的选择性的理由。此外,通过X射线结构分析表征了该发明的几种化合物与T. brucei CYP51(TbCYP51)同源物的结合方式。口服活性化合物及其环糊精复合物已被证明对克氏病感染的小鼠有效。
  • [EN] TRICYCLIC TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY<br/>[FR] COMPOSÉS TRIAZOLES TRICYCLIQUES MODULANT L'ACTIVITÉ HSP90
    申请人:SYNTA PHARMACEUTICALS CORP
    公开号:WO2009139916A1
    公开(公告)日:2009-11-19
    The present invention relates to substituted tricyclic triazole compounds and compositions comprising substituted tricyclic triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.
    本发明涉及替代三环三唑化合物和包含替代三环三唑化合物的组合物。该发明还涉及在需要的受体中抑制Hsp90活性的方法,以及预防或治疗高增殖性疾病(如癌症)的方法,其中包括向受体施用本发明的化合物或包含这种化合物的组合物。
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