1-[4-Chloro-2-(4-methoxyphenyl)sulfanylphenyl]piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[4-Chloro-2-(4-methoxyphenyl)sulfanylphenyl]piperazine
• 化学式: C₁₇H₁₉ClN₂OS
• 分子量: 334.9
• InChiKey: AQIRPOAARAHUND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors
  申请人：H. Lundbeck A/S

  公开号：US20160137620A1

  公开（公告）日：2016-05-19

  The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

  这项发明提供了由一般式I表示的化合物，其中取代基在申请中定义。这些化合物在治疗情感障碍方面非常有用，包括抑郁症、焦虑障碍（包括广泛性焦虑障碍和恐慌障碍）以及强迫症。
• [EN] PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS<br/>[FR] DERIVES DE PHENYL-PIPERAZINE EN TANT QU'INHIBITEURS DU RECAPTAGE DE LA SEROTONINE
  申请人：LUNDBECK & CO AS H

  公开号：WO2003029232A1

  公开（公告）日：2003-04-10

  The invention provides compounds represented by the general formula I Iwherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

  本发明提供了由一般公式I I所表示的化合物，其中取代基在申请中定义。该化合物在治疗情感障碍中有用，包括抑郁症，焦虑障碍，包括普通焦虑障碍和恐慌障碍以及强迫症。
• Phenyl-piperazine derivatives as serotonin reuptake inhibitors
  申请人：Ruhland Thomas

  公开号：US20060089368A1

  公开（公告）日：2006-04-27

  The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

  该发明提供了一种由一般式I所表示的化合物，其中取代基在申请中有定义。这些化合物在治疗情感障碍中非常有用，包括抑郁症、焦虑症，包括广泛性焦虑症和惊恐障碍以及强迫症。
• PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS
  申请人：Ruhland Thomas

  公开号：US20070060574A1

  公开（公告）日：2007-03-15

  The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

  本发明提供的化合物由一般式I表示，其中取代基在申请中已定义。这些化合物在治疗情感障碍中非常有用，包括抑郁症、焦虑障碍，包括广泛性焦虑障碍和惊恐障碍以及强迫症。
• PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS
  申请人：Ruhland Thomas

  公开号：US20110009423A1

  公开（公告）日：2011-01-13

  The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

  本发明提供的化合物由一般式I所表示，其中取代基在申请中定义。这些化合物在治疗情感障碍方面具有用途，包括抑郁症、焦虑症（包括普遍性焦虑障碍和恐慌症）和强迫症。