(E)-N-[3-[4-[3-[[(E)-octadec-9-enyl]amino]propyl]piperazin-1-yl]propyl]octadec-9-en-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (E)-N-[3-[4-[3-[[(E)-octadec-9-enyl]amino]propyl]piperazin-1-yl]propyl]octadec-9-en-1-amine
• 化学式: C₄₆H₉₂N₄
• 分子量: 701.2
• InChiKey: FRTWLDVIFSHXKN-XPWSMXQVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.7
• 重原子数：
  50
• 可旋转键数：
  40
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  30.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Novel reagents for transfection of eukaryotic cells
  申请人：Jessee Joel

  公开号：US20090023215A1

  公开（公告）日：2009-01-22

  Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.

  本发明提供了用于改进将大分子传递到真核细胞的组合物和方法。来自非包膜病毒融合蛋白的融合肽增强了由阳离子脂质、多阳离子聚合物（如PEI）和树状分子等转染剂介导的真核细胞转染效率。这些融合肽作为转染复合物的一部分，有效地将大分子（例如核酸）传递到真核细胞中。本发明还提供了新型阳离子脂质和阳离子脂质组合物，可用于将大分子（如核酸、蛋白质和肽）引入各种细胞和组织中。这些脂质可以单独使用，与其他脂质结合使用和/或与融合肽结合使用以制备转染复合物。
• NOVEL REAGENTS FOR TRANSFECTION OF EUKARYOTIC CELLS
  申请人：Jessee Joel

  公开号：US20120052574A1

  公开（公告）日：2012-03-01

  Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.

  提供了一种改进大分子进入真核细胞的组合物和方法。来自非包膜病毒融合蛋白的融合肽增强了由阳离子脂质、聚阳离子聚合物（如PEI）和树状分子等转染剂介导的真核细胞转染的效率。这些融合肽作为转染复合物的一部分，有效地将大分子（例如核酸）传递到真核细胞中。还提供了新型阳离子脂质和阳离子脂质组合物，可用于将大分子（如核酸、蛋白质和肽）引入各种细胞和组织中。这些脂质可以单独使用，与其他脂质结合使用和/或与融合肽结合使用以制备转染复合物。
• US7915230B2
  申请人：——

  公开号：US7915230B2

  公开（公告）日：2011-03-29
• US8759499B2
  申请人：——

  公开号：US8759499B2

  公开（公告）日：2014-06-24