4-[2-[4-(4-fluorophenyl)piperazin-1-yl]ethylamino]-1H-pyridazin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[2-[4-(4-fluorophenyl)piperazin-1-yl]ethylamino]-1H-pyridazin-6-one
• 化学式: C₁₆H₂₀FN₅O
• 分子量: 317.36
• InChiKey: NTTYWJGVUNURRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  60
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED ALKYL-PYRIDAZINONES FOR THE TREATMENT OF MEMORY AND LEARNING MALFUNCTIONS<br/>[FR] ALKYLE-PYRIDAZINONES SUBSTITUES POUR LE TRAITEMENT DE DYSFONCTIONNEMENTS DE LA MEMOIRE ET DE L'APPRENTISSAGE
  申请人：EGYT GYOGYSZERVEGYESZETI GYAR

  公开号：WO2004043465A1

  公开（公告）日：2004-05-27

  The compounds of the general Formula I, wherein R1 stands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, R2 is hydrogen or lower alkyl; n is 1, 2 or 3; R3 is hydrogen, lower alkyl or aryl-lower alkyl; Z is -0-; or R3 and Z together with the intermediate atoms form a piperazino ring; Q and W independently from each other stands for -CH= or -N=; and R4, R5 and R6 can be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or R4 and R5 together form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.

  通式I的化合物，其中R1代表氢或低碳基；符号X和Y中的一个代表氢或卤素，另一个代表通式II的基团，其中R2代表氢或低碳基；n为1、2或3；R3代表氢、低碳基或芳基-低碳基；Z为-0-；或者R3和Z与中间原子一起形成哌嗪环；Q和W独立地代表-CH=或-N=；R4、R5和R6可以相同也可以不同，代表氢、卤素、三氟甲基或低烷氧基；或者R4和R5一起形成乙二氧基基团。这些化合物及其药学上可接受的盐可以用于治疗或预防记忆失灵和/或认知衰退或预防学习能力下降。
• Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
  申请人：Barkoczy Jozsef

  公开号：US20050043314A1

  公开（公告）日：2005-02-24

  New substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R 1 is hydrogen or alkyl having 1-4 carbon atoms; X is hydrogen or halogen; R 2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Q and W independently from each other stand for —N═ or —CH═; and R 4 and R 5 independently from each other represent hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof possess useful anxiolytic and cognition enhancing properties.

  通式(I)的新取代烷基氨基哒嗪酮衍生物，（其中 R 1 是氢或具有 1-4 个碳原子的烷基；X 是氢或卤素；R 2 是氢或具有 1-4 个碳原子的烷基；n 是 1、2 或 3；Q 和 W 各自代表-N═或-CH═；以及 R 4 和 R 5 分别代表氢、卤素、三氟甲基或具有 1-4 个碳原子的烷氧基）及其药学上可接受的酸加成盐具有抗焦虑和增强认知的作用。
• Substituted alkyl-pyridazinones for the treatment of memory and learning malfunctions
  申请人：Levay Gyorgy

  公开号：US20060211703A1

  公开（公告）日：2006-09-21

  The compounds of the general Formula I, wherein R 1 stands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, R 2 is hydrogen or lower alkyl; n is 1, 2 or 3; R 3 is hydrogen, lower alkyl or aryl-lower alkyl; Z is -0-; or R 3 and Z together with the intermediate atoms form piperazino ring; Q and W independently from each other stands for —CH═ or —N═; and R 4 , R 5 and R 6 can be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or R 4 and R 5 together form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.

  通式 I 的化合物，其中 R 1 代表氢或低级烷基；符号 X 和 Y 中的一个代表氢或卤素，另一个代表通式 II 中的基团，R 2 是氢或低级烷基；n 是 1、2 或 3；R 3 是氢、低级烷基或芳基-低级烷基；Z 是-0-；或 R 3 和 Z 与中间原子一起形成哌嗪环；Q 和 W 各自代表 -CH═ 或 -N═；以及 R 4 , R 5 和 R 6 可以相同或不同，代表氢、卤素、三氟甲基或低级烷氧基；或 R 4 和 R 5 及其药学上可接受的盐类可用于治疗或预防记忆障碍和/或认知能力下降或预防学习能力下降。
• SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Egis Gyogyszergyar Rt.

  公开号：EP1430034B1

  公开（公告）日：2005-02-09
• SUBSTITUTED ALKYL-PYRIDAZINONES FOR THE TREATMENT OF MEMORY AND LEARNING MALFUNCTIONS
  申请人：EGIS GYOGYSZERGYAR RT.

  公开号：EP1567159A1

  公开（公告）日：2005-08-31