4-Phenyl-1-(1-phenylethyl)piperidin-4-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-Phenyl-1-(1-phenylethyl)piperidin-4-ol
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: PKTJCXJTMHJHNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-羟基-4-苯基哌啶盐酸盐 、 alkaline earth salt of/the/ methylsulfuric acid 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 4-Phenyl-1-(1-phenylethyl)piperidin-4-ol
  参考文献：
  名称：

  Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1

  摘要：

  A series of 4-hydroxy-4-phenylpiperidines have been synthesized and bind to the nociceptin receptor with high affinity. The synthesis and structure-activity relationships at the N-1 and C-4 are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.061

文献信息

• Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1
  作者：Ginny D. Ho、Ana Bercovici、Deen Tulshian、William J. Greenlee、Ahmad Fawzi、April Smith Torhan、Hongtao Zhang

  DOI：10.1016/j.bmcl.2007.03.061

  日期：2007.6

  A series of 4-hydroxy-4-phenylpiperidines have been synthesized and bind to the nociceptin receptor with high affinity. The synthesis and structure-activity relationships at the N-1 and C-4 are described. (C) 2007 Elsevier Ltd. All rights reserved.