(3R)5-{1-[4-(3-chlorophenyl)-3-oxo-piperazin-1-yl]-methanoyl}-3-(4-cyanophenyl)-2,3-dihydro-imidazo[2,1-b]thiazole | 367910-46-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (3R)5-{1-[4-(3-chlorophenyl)-3-oxo-piperazin-1-yl]-methanoyl}-3-(4-cyanophenyl)-2,3-dihydro-imidazo[2,1-b]thiazole
• 英文别名: 4-[(3R)-5-[4-(3-chlorophenyl)-3-oxopiperazine-1-carbonyl]-2,3-dihydroimidazo[2,1-b][1,3]thiazol-3-yl]benzonitrile
• CAS: 367910-46-1
• 化学式: C₂₃H₁₈ClN₅O₂S
• 分子量: 463.947
• InChiKey: WPRCWPKITFOKNL-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (3R)5-{1-[4-(3-chlorophenyl)-3-oxo-piperazin-1-yl]-methanoyl}-3-(4-cyanophenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 在 盐酸 作用下， 以 甲醇 为溶剂， 生成 methyl N-{2-[(3-chlorophenyl)amino]ethyl}-N-{[3-(4-cyanophenyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl]carbonyl}glycinate Bishydrochloride
  参考文献：
  名称：

  INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

  摘要：

  本发明涉及抑制异戊二烯蛋白转移酶和癌基因蛋白Ras的预尾基类似物化合物。该发明进一步涉及含有本发明化合物的化疗组合物以及用于抑制异戊二烯蛋白转移酶和癌基因蛋白Ras的预尾基化的方法。

  公开号：

  US20020045759A1

文献信息

• Inhibitors of prenyl-protein transferase
  申请人：——

  公开号：US20040110764A1

  公开（公告）日：2004-06-10

  The present invention is directed to peptidomimetic compounds that inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

  本发明涉及抑制戊烯基蛋白转移酶和癌基因蛋白Ras的戊烯基化的肽类类似物化合物。本发明还涉及包含本发明化合物的化疗组合物和抑制戊烯基蛋白转移酶和癌基因蛋白Ras的方法。
• [EN] INHIBITORS OF PRENYL-PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS DE PRENYLE PROTEINE TRANSFERASE
  申请人：MERCK & CO INC

  公开号：WO2001076693A1

  公开（公告）日：2001-10-18

  The present invention is directed to peptidomimetic compounds that inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
• INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
  申请人：——

  公开号：US20020045759A1

  公开（公告）日：2002-04-18

  The present invention is directed to peptidomimetic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

  本发明涉及抑制异戊二烯蛋白转移酶和癌基因蛋白Ras的预尾基类似物化合物。该发明进一步涉及含有本发明化合物的化疗组合物以及用于抑制异戊二烯蛋白转移酶和癌基因蛋白Ras的预尾基化的方法。