Allyl-isopropyl-acetylharnstoff

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: Allyl-isopropyl-acetylharnstoff
• 英文别名: N-propan-2-yl-N-(prop-2-enylcarbamoyl)acetamide
• 化学式: C₉H₁₆N₂O₂
• 分子量: 184.24
• InChiKey: JQZOGNFCXFRFRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ACYL-UREA DERIVATIVES AND USES THEREOF
  申请人：Bialer Meir

  公开号：US20100280124A1

  公开（公告）日：2010-11-04

  Novel acyl-urea containing compounds, processes of preparing same, compositions containing same and uses thereof in the treatment of neurological diseases and disorders such as epilepsy, neuropathic pain, bipolar disorder, status epilepticus, chemically-induced convulsions and/or seizure disorders, febrile convulsions conditions, metabolic disturbances and a sustenance withdrawal conditions, are provided. Also provided are uses of these and other acyl-urea containing compounds in the treatment of neurological diseases and disorders.

  提供了含有新型酰基脲的化合物、制备该化合物的方法、含有该化合物的组合物以及在治疗神经系统疾病和障碍（如癫痫、神经病性疼痛、躁郁症、持续性癫痫、化学诱导的惊厥和/或癫痫障碍、热性惊厥病症、代谢紊乱和戒断症状）中使用该化合物的方法。还提供了这些和其他含酰基脲的化合物在治疗神经系统疾病和障碍中的用途。
• ANALGESIC
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0661050A1

  公开（公告）日：1995-07-05

  An analgesic composition which can reduce the side effects caused by ibuprofen, such as the disturbance of a gastric mucous membrane, by adding dicyclomine hydrochloride to ibuprofen to potentiate the analgesic activity.

  一种镇痛组合物，通过在布洛芬中加入盐酸双环胺来增强镇痛活性，从而减少布洛芬引起的副作用，如胃黏膜不适。
• COMBINED ANTIPYRETIC ANALGESIC DRUG
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0812589A1

  公开（公告）日：1997-12-17

  A combined antipyretic analgesic drug having an excellent antipyretic analgesic effect and reduced side effects, such as gastrointestinal disorder, and comprising a combination of ibusprofen with isopropylantipyrine in a ratio by weight of preferably 5:1 to 1:5, still preferably 3:1 to 1:3. Preferable examples of the dosage form include a three-layer tablet comprising the first layer containing ibusprofen and the third layer containing isopropylantipyrine and, sandwiched between these layers, the second layer containing an inactive ingredient, and a dry coated tablet having, enclosed therein, a core tablet containing ibuprofen or isopropylantipyrine.

  一种解热镇痛联合用药，具有良好的解热镇痛效果，减少副作用，如胃肠功能紊乱，由伊布洛芬和异丙基安替比林组成，其重量比最好为5:1至1:5，最好为3:1至1:3。优选的剂型包括三层片剂，第一层含有布洛芬，第三层含有异丙基安替比林，夹在这两层之间的第二层含有非活性成分，以及干包衣片剂，其中包有含有布洛芬或异丙基安替比林的片芯。
• PROCESS FOR PRODUCING HARD CAPSULE
  申请人：Shionogi Qualicaps Co., Ltd.

  公开号：EP1044682A1

  公开（公告）日：2000-10-18

  A method of manufacturing hard capsules is characterized by comprising the steps of dispersing a water-soluble cellulose derivative in hot water and cooling the dispersion to effect dissolution of the water-soluble cellulose derivative in the water, adding and dissolving a gelling agent in the water-soluble cellulose derivative solution to give a capsule-preparing solution, dipping a capsule-forming pin into the capsule-preparing solution at a predetermined temperature, then drawing out the pin and inducing gelation of the capsule-preparing solution adhering to the pin.

  一种制造硬胶囊的方法，其特征在于包括以下步骤：将水溶性纤维素衍生物分散在热水中，然后冷却分散液，使水溶性纤维素衍生物溶解在水中、在水溶性纤维素衍生物溶液中加入并溶解胶凝剂，得到胶囊制备溶液，在预定温度下将胶囊成型针浸入胶囊制备溶液中，然后拔出针，使粘附在针上的胶囊制备溶液凝胶化。
• SOLID PREPARATION CONTAINING SPARINGLY SOLUBLE NSAIDS
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1103258A1

  公开（公告）日：2001-05-30

  A readily absorbable solid composition comprising sparingly soluble NSAIDs of the propionic acid type, a water-soluble polymeric base, and a nonionic surfactant.

  一种易于吸收的固体组合物，由丙酸类难溶性非甾体抗炎药、水溶性聚合物基和非离子表面活性剂组成。