2-[4-(phenylmethyl)piperazin-1-yl]-6-pyridin-4-ylpyrimidin-4(1H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(phenylmethyl)piperazin-1-yl]-6-pyridin-4-ylpyrimidin-4(1H)-one
• 英文别名: 2-(4-benzylpiperazin-1-yl)-4-pyridin-4-yl-1H-pyrimidin-6-one
• 化学式: C₂₀H₂₁N₅O
• 分子量: 347.42
• InChiKey: KUXVPEYTUNQVFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] 2-[NITROGEN-HETEROCYCLIC]PYRIMIDONE DERIVATIVES<br/>[FR] DERIVES DE LA 2-[AZOTE-HETEROCYCLIQUE]PYRIMIDONE
  申请人：SANOFI SYNTHELABO

  公开号：WO2001070728A1

  公开（公告）日：2001-09-27

  A pyrimidone derivative represented by formula (I) or a salt thereof wherein: R1 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4 alkyl group, C1-4 alkoxy group or a halogen atom; (a) represents a [nitrogen-heterocyclic ring] of formula (X), (Y) or (Z). And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β such as Alzheimer's disease.