4-Oxo-4-[4-(2-phenoxyethoxycarbonyl)piperazin-1-yl]-3-(phosphonomethyl)butanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-Oxo-4-[4-(2-phenoxyethoxycarbonyl)piperazin-1-yl]-3-(phosphonomethyl)butanoic acid
• 化学式: C₁₈H₂₅N₂O₉P
• 分子量: 444.4
• InChiKey: ZTEQITVKEFPQLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  154
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Phosphinylmethyl and phosphorylmethyl succinic and glutauric acid analogs as B-secretase inhibitors
  申请人：——

  公开号：US20020187928A1

  公开（公告）日：2002-12-12

  The invention provides a compound of formula (I): 1 or salts or hydrates thereof, useful as beta-secretase inhibitors. The invention further relates to a method of reducing plaque formation, particularly useful in the treatment of Alzheimer's disease.

  本发明提供了一种式 (I) 的化合物： 1 或其盐类或水合物，可用作β-分泌酶抑制剂。本发明还涉及一种减少斑块形成的方法，尤其适用于治疗阿尔茨海默氏症。
• Phosphinylmethyl and phosphorylmethyl succinic and glutaric acid analogs as beta-secretase inhibitors
  申请人：Neurologic, Inc.

  公开号：US20030078240A1

  公开（公告）日：2003-04-24

  The invention provides a compound of formula (I): 1 or salts or hydrates thereof, useful as beta-secretase inhibitors. The invention further relates to a method of reducing plaque formation, particularly useful in the treatment of Alzheimer's disease.

  本发明提供了一种式 (I) 的化合物： 1 或其盐类或水合物，可用作β-分泌酶抑制剂。本发明还涉及一种减少斑块形成的方法，尤其适用于治疗阿尔茨海默氏症。
• US6562783B2
  申请人：——

  公开号：US6562783B2

  公开（公告）日：2003-05-13
• [EN] PHOSPHINYLMETHYL AND PHOSPHORYLMETHYL SUCCINIC AND GLUTARIC ACID ANALOGS AS beta -SECRETASE INHIBITORS<br/>[FR] ANALOGUES D'ACIDES PHOSPHINYLMETHYL ET PHOSPHORYLMETHYL SUCCINIQUES ET GLUTARIQUES UTILISES COMME INHIBITEURS DE LA beta -SECRETASE
  申请人：NEUROLOGIC INC

  公开号：WO2002096897A1

  公开（公告）日：2002-12-05

  The invention provides a compound of formula (I), or salts or hydrates thereof, useful as beta-secretase inhibitors. The invention further relates to a method of reducing plaque formation, particularly useful in the treatment of Alzheimer's disease.