1-[6-(thiophen-3-ylmethoxy)-5-trifluoromethyl-pyridin-2-yl]-piperazine, acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[6-(thiophen-3-ylmethoxy)-5-trifluoromethyl-pyridin-2-yl]-piperazine, acetate
• 英文别名: Acetic acid;1-[6-(thiophen-3-ylmethoxy)-5-(trifluoromethyl)pyridin-2-yl]piperazine
• 化学式: C₂H₄O₂*C₁₅H₁₆F₃N₃OS
• 分子量: 403.425
• InChiKey: ZFAHGSNVXMFRGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.24
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• NOVEL COMPOUNDS AND THEIR USE
  申请人：Biovitrum AB

  公开号：EP1506185A1

  公开（公告）日：2005-02-16
• [EN] NOVEL COMPOUNDS AND THEIR USE<br/>[FR] NOUVEAUX COMPOSES ET LEUR UTILISATION
  申请人：BIOVITRUM AB

  公开号：WO2003097636A1

  公开（公告）日：2003-11-27

  Compounds of the general formula (I): wherein R1, R2, R3 and R4 are as described in the specification. Further included are pharmaceutical compositions comprising the compounds, processes for their preparation, as well as the use of the compounds for the preparation of a medicament which particularly acts on the central nervous system, particularly for use as anti-obesity agents.