N2-[2-(4-Fluorophenoxy)ethyl]-N4-[(1S)-1-(4-fluorophenyl)ethyl]-1,3,5-triazine-2,4,6-triamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: N2-[2-(4-Fluorophenoxy)ethyl]-N4-[(1S)-1-(4-fluorophenyl)ethyl]-1,3,5-triazine-2,4,6-triamine
• 英文别名: 4-N-[2-(4-fluorophenoxy)ethyl]-2-N-[(1S)-1-(4-fluorophenyl)ethyl]-1,3,5-triazine-2,4,6-triamine
• 化学式: C₁₉H₂₀F₂N₆O
• 分子量: 386.404
• InChiKey: UNUSDSJWMRJMCT-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  98
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  (S)-(-)-1-(4-氟苯基)乙胺 在 ammonium hydroxide 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 N2-[2-(4-Fluorophenoxy)ethyl]-N4-[(1S)-1-(4-fluorophenyl)ethyl]-1,3,5-triazine-2,4,6-triamine
  参考文献：
  名称：

  Aminotriazine 5-HT7 antagonists

  摘要：

  The present studies have identified a series of aminotriazines as novel 5-HT7 receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT7 receptor and do not bind to either the 5-HT2C or 5-HT6 receptors. These compounds produce no agonist effects by themselves, and shift the dose-response curve of 5-CT to the right in the manner of an antagonist. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.008

文献信息

• 5-HT7 receptor antagonists
  申请人：——

  公开号：US20020032199A1

  公开（公告）日：2002-03-14

  Amino-pyrimidine and amino-triazine derivatives having 5-HT 7 antagonist activity for the treatment of sleeping disorders, depression, schizophrenia, anxiety, obsessive compulsive disorders, circadian rhythm disorders, ocular disorders and/or centrally and peripherally mediated hypertension are provided.

  提供具有5-HT7拮抗活性的氨基嘧啶和氨基三嗪衍生物，用于治疗睡眠障碍、抑郁症、精神分裂症、焦虑症、强迫症、昼夜节律紊乱、眼部疾病和/或中枢和外周介导的高血压。
• 5-HT 7 RECEPTOR ANTAGONISTS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1280781B1

  公开（公告）日：2009-11-18
• US6630469B2
  申请人：——

  公开号：US6630469B2

  公开（公告）日：2003-10-07
• Aminotriazine 5-HT7 antagonists
  作者：Ronald J Mattson、Derek J Denhart、John D Catt、Michael F Dee、Jeffrey A Deskus、Jonathan L Ditta、James Epperson、H Dalton King、Aiming Gao、Michael A Poss、Ashok Purandare、David Tortolani、Yufen Zhao、Hua Yang、Suresh Yeola、Jane Palmer、John Torrente、Arlene Stark、Graham Johnson

  DOI：10.1016/j.bmcl.2004.06.008

  日期：2004.8

  The present studies have identified a series of aminotriazines as novel 5-HT7 receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT7 receptor and do not bind to either the 5-HT2C or 5-HT6 receptors. These compounds produce no agonist effects by themselves, and shift the dose-response curve of 5-CT to the right in the manner of an antagonist. (C) 2004 Elsevier Ltd. All rights reserved.