1,4-Dihydro-4-[3-[[[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-Dihydro-4-[3-[[[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester
• 英文别名: Dimethyl 4-[3-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylcarbamoylamino]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 化学式: C₃₂H₄₁N₅O₆
• 分子量: 591.707
• InChiKey: HSUYTMPXLKOBTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  43
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  1-(3-氨基)-4-(2-甲氧基苯基)哌嗪 、 1,4-dihydro-4-(3-isocyanatophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester 以 二氯甲烷 为溶剂， 生成 1,4-Dihydro-4-[3-[[[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester
  参考文献：
  名称：

  Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists

  摘要：

  Dihydropyridine 5a was found to be an inhibitor of neuropeptide Y-1 binding in a high throughput I-125-PYY screening assay. Structure-activity studies around certain portions of the dihydropyridine chemotype identified BMS-193885 (6e) as a potent and selective Y-1 receptor antagonist. In a forskolin-stimulated c-AMP production assay using CHO cells expressing the human Y-1 receptor, 6e demonstrated full functional antagonism (K-b = 4.5 nM). Compound 6e inhibited NPY-induced feeding in satiated rats when dosed at 3.0 and 10.0 mg/kg (ip), and also decreased spontaneous overnight food consumption in rats at doses of 10 and 20 mg/kg (ip). (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00761-2

文献信息

• [EN] SELECTIVE DOPAMIN D3 RECEPTOR AGONISTS FOR THE TREATMENT OF SEXUAL DYSFUNCTION<br/>[FR] AGONISTES SELECTIFS DU RECEPTEUR DE LA DOPAMINE D3 POUR TRAITER LES TROUBLES D'ORDRE SEXUEL
  申请人：PFIZER LTD

  公开号：WO2003051370A1

  公开（公告）日：2003-06-26

  The use of a composition comprising a selective dopamine D3 receptor agonist, wherein said dopamine D3 receptor agonist is at least about 15-times more functionally selective for a dopamine D3 receptor as compared with a dopamine D2 receptor when measured using the same functional assay, in the preparation of a medicament for the treatment and/or prevention of sexual dysfunction.

  使用一种包含选择性多巴胺D3受体激动剂的组合物，其中所述的多巴胺D3受体激动剂在使用相同的功能性测定时，与多巴胺D2受体相比至少具有15倍的功能选择性，用于制备治疗和/或预防性功能障碍的药物。
• Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists
  作者：Graham S. Poindexter、Marc A. Bruce、Karen L. LeBoulluec、Ivo Monkovic、Scott W. Martin、Eric M. Parker、Larry G. Iben、Rachel T. McGovern、Astrid A. Ortiz、Jennifer A. Stanley、Gail K. Mattson、Michael Kozlowski、Meredith Arcuri、Ildiko Antal-Zimanyi

  DOI：10.1016/s0960-894x(01)00761-2

  日期：2002.2

  Dihydropyridine 5a was found to be an inhibitor of neuropeptide Y-1 binding in a high throughput I-125-PYY screening assay. Structure-activity studies around certain portions of the dihydropyridine chemotype identified BMS-193885 (6e) as a potent and selective Y-1 receptor antagonist. In a forskolin-stimulated c-AMP production assay using CHO cells expressing the human Y-1 receptor, 6e demonstrated full functional antagonism (K-b = 4.5 nM). Compound 6e inhibited NPY-induced feeding in satiated rats when dosed at 3.0 and 10.0 mg/kg (ip), and also decreased spontaneous overnight food consumption in rats at doses of 10 and 20 mg/kg (ip). (C) 2002 Elsevier Science Ltd. All rights reserved.