2-Chloro-1-(4-(2-morpholino-2-oxoethyl)piperazin-1-yl)ethan-1-one | 900641-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-Chloro-1-(4-(2-morpholino-2-oxoethyl)piperazin-1-yl)ethan-1-one
• 英文别名: 2-[4-(2-chloroacetyl)piperazin-1-yl]-1-morpholin-4-ylethanone
• CAS: 900641-12-5
• 化学式: C₁₂H₂₀ClN₃O₃
• 分子量: 289.76
• InChiKey: YGHXRSQVSHCCID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  53.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• In vivo engineered cereblon protein
  申请人：Vividion Therapeutics, Inc.

  公开号：US10781239B2

  公开（公告）日：2020-09-22

  Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO:2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO:2 or 3.

  本文公开了体内工程化脑龙蛋白及其制造方法。体内工程化脑龙蛋白可包括 SEQ ID NO:1 所列半胱氨酸 287 或 SEQ ID NO:2 或 3 所列半胱氨酸 286 的位点特异性非天然发生修饰，该修饰包括外源迈克尔受体与 SEQ ID NO:1 所列半胱氨酸 287 或 SEQ ID NO:2 或 3 所列半胱氨酸 286 之间的体内迈克尔加成反应产生的分子。
• IN VIVO ENGINEERED CEREBLON PROTEIN
  申请人：Vividion Therapeutics, Inc.

  公开号：US20200216507A1

  公开（公告）日：2020-07-09

  Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3.