1-(3-methoxy-propyl)-piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(3-methoxy-propyl)-piperidine
• 英文别名: 1-(3-Methoxy-propyl)-piperidin；1-(3-Methoxypropyl)piperidine
• 化学式: C₉H₁₉NO
• 分子量: 157.256
• InChiKey: ZVASECAMKNOBPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-methoxy-propyl)-piperidine 、 氢碘酸 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Gabriel; Colman, Chemische Berichte, 1906, vol. 39, p. 2875,2882

  摘要：

  DOI：
• 作为产物：
  描述：

  哌啶 、 3-氯丙基甲基醚 生成 1-(3-methoxy-propyl)-piperidine
  参考文献：
  名称：

  Gabriel; Colman, Chemische Berichte, 1906, vol. 39, p. 2875,2882

  摘要：

  DOI：

文献信息

• DIAZABICYCLO[4.3.1]DECANE DERIVATIVES FOR TREATMENT OF PSYCHIATRIC DISORDERS
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

  公开号：US20170002003A1

  公开（公告）日：2017-01-05

  The present invention relates to diazabicyclo[4.3.1]decane derivatives, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said diazabicyclo[4.3.1]decane derivatives can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.

  本发明涉及二氮杂双环[4.3.1]癸烷衍生物，这些化合物的药用盐以及含有至少一种这些化合物的药用载体、赋形剂和/或稀释剂的药物组合物。所述的二氮杂双环[4.3.1]癸烷衍生物可用于预防和/或治疗精神障碍和神经退行性疾病、障碍和症状。
• MELAMPOMAGNOLIDE B DERIVATIVES
  申请人：Janganati Venumadhav

  公开号：US20150133444A1

  公开（公告）日：2015-05-14

  The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, and thiocarbamates. The derivatives may be synthesized via an MMB triazole intermediate. These derivatives are useful for treating cancer in humans.

  本公开提供了槲皮素B（MMB）的衍生物，包括碳酸酯、氨基甲酸酯和硫代氨基甲酸酯。这些衍生物可以通过MMB三唑中间体合成。这些衍生物对于治疗人类癌症是有用的。
• 5 OXO-5,8-DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES
  申请人：BEAUVERGER Philippe

  公开号：US20120277220A1

  公开（公告）日：2012-11-01

  The present invention relates to 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives, to their preparation and to their therapeutic use.

  本发明涉及5-氧代-5,8-二氢吡啶并[2,3-d]嘧啶衍生物，其制备和治疗用途。
• PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF
  申请人：CHERRIER Marie-Pierre

  公开号：US20090197866A1

  公开（公告）日：2009-08-06

  The disclosure relates to compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the disclosure, to the compositions containing them and to the use thereof as medicaments, in particular as anticancer agents. The disclosure also relates to the process for preparing the compounds of formula (I) and to reaction intermediates.

  该公开涉及式(I)的化合物：其中R1、R2、R3、R4和R5如公开所定义，以及含有它们的组合物以及将其用作药物，特别是抗癌剂的用途。该公开还涉及制备式(I)的化合物的过程以及反应中间体。
• [EN] NOVEL COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF<br/>[FR] NOUVEAU COMPOSÉ, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
  申请人：DAEGU GYEONGBUK MEDICAL INNOVATION FOUND

  公开号：WO2021145729A1

  公开（公告）日：2021-07-22

  The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

  本发明涉及一种制备具有选择性功能化酪氨酸的生物材料的方法，具有选择性功能化酪氨酸的生物材料，以及含有该生物材料作为活性成分的药物组合物。本发明的一种制备生物材料的方法，其中将由式2表示的化合物偶联到生物材料，使得该化合物能够选择性地偶联到酪氨酸，且在生物材料中的产率较高，酪氨酸位于水溶液表面，使得其与酪氨酸以外的氨基酸不发生偶联，当只有一个酪氨酸存在时，不会出现异质混合物，同时保持生物材料的固有活性，因此该化合物可以有效地用作含有生物材料药物的药物组合物的活性成分。此外，该方法可以选择性功能化酪氨酸，因此可以有效地用于生物材料中的酪氨酸功能化。