2-[(1-tert-butoxycarbonylpiperidine-4-yl)oxy]-N,N-dimethylethylamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-[(1-tert-butoxycarbonylpiperidine-4-yl)oxy]-N,N-dimethylethylamine
• 英文别名: 2-[(1-tert-butoxycarbonylpiperidin-4-yl)oxy]-N,N-dimethylethylamine；tert-butyl 4-[2-(dimethylamino)ethoxy]piperidine-1-carboxylate
• 化学式: C₁₄H₂₈N₂O₃
• 分子量: 272.388
• InChiKey: USBJUDTUEWAOGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[(1-tert-butoxycarbonylpiperidine-4-yl)oxy]-N,N-dimethylethylamine 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 7.0h， 生成 N,N-dimethyl-2-(piperidin-4-yloxy)ethylamine dihydrochloride
  参考文献：
  名称：

  EP1806347

  摘要：

  公开号：
• 作为产物：
  描述：

  2-氯-N,N-二甲基乙胺 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.58h， 生成 2-[(1-tert-butoxycarbonylpiperidine-4-yl)oxy]-N,N-dimethylethylamine
  参考文献：
  名称：

  EP1806347

  摘要：

  公开号：

文献信息

• [EN] NEW ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS AND USES IN TREATMENTS OF OBESITY AND DIABETES MELLITUS - 087<br/>[FR] NOUVEAUX INHIBITEURS DE L'ACÉTYL COENZYME A CARBOXYLASE (ACC) ET UTILISATIONS DANS LE TRAITEMENT DE L'OBÉSITÉ ET DU DIABÈTE SUCRÉ - 087
  申请人：ASTRAZENECA AB

  公开号：WO2009082346A1

  公开（公告）日：2009-07-02

  The present invention relates to Acetyl Coenzyme A Carboxylase (ACC) inhibitors according to formula (I), or an enantiomer thereof, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, E, L, Z and n are as defined herein, to processes for preparing such compounds, to pharmaceutical compositions containing them, to the use of such inhibitors and to methods for th eir therapeutic use, particularly in the treatments of obesity and diabetes mellitus.

  本发明涉及根据式（I）的乙酰辅酶A羧化酶（ACC）抑制剂，或其对映体，或其药用可接受的盐，其中R1、R2、R3、R4、R5、E、L、Z和n的定义如本文所述，以及制备此类化合物的方法，含有它们的药物组合物，使用这种抑制剂以及用于它们的治疗用途的方法，特别是用于肥胖和糖尿病的治疗。
• Aromatic-Ring-Fused Pyrimidine Derivative
  申请人：Yonetoku Yasuhiro

  公开号：US20070249587A1

  公开（公告）日：2007-10-25

  There are provided novel pyrimidine derivatives which has been fused with an aromatic heterocycle selected from thiophene, thiazole and pyridine or pharmaceutically acceptable salts thereof; and a pharmaceutical composition comprising said compound as an active ingredient. These compounds exhibit excellent promoting activity on insulin secretion and activity against hyperglycemia. Hence, the pharmaceutical compositions comprising such compounds as active ingredients, based on these actions, are useful for treating and/or preventing insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes), insulin-resistant diseases, obesity, and the like.

  提供了一种新颖的嘧啶衍生物，其已与从噻吩、噻唑和吡啶中选择的芳香杂环或其药学上可接受的盐融合；以及包含该化合物作为活性成分的制药组合物。这些化合物表现出促进胰岛素分泌和对高血糖的活性的优异作用。因此，基于这些作用，包含这些化合物作为活性成分的制药组合物对于治疗和/或预防胰岛素依赖性糖尿病（1型糖尿病）、非胰岛素依赖性糖尿病（2型糖尿病）、胰岛素抵抗性疾病、肥胖症等是有用的。
• Pyrimidine Derivative Condensed with a Non-Aromatic Ring
  申请人：Yonetoku Yasuhiro

  公开号：US20080070896A1

  公开（公告）日：2008-03-20

  There are provided new pyrimidine derivatives condensed with a non-aromatic ring selected from dihydrothiophene, dihydrofuran, cycloalkane moiety, and the like or pharmaceutically acceptable salts thereof; and a pharmaceutical composition comprising said compound as an active ingredient. These compounds exhibit excellent promoting activity on insulin secretion and activity against hyperglycemia. Hence, the pharmaceutical compositions comprising such compounds as active ingredients, based on these actions, are useful for treating and/or preventing insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes), insulin-resistant diseases, obesity, and the like.

  提供了一些新的嘧啶衍生物，其与二氢噻吩、二氢呋喃、环烷基等非芳香环结构缩合，或其药学上可接受的盐缩合；以及一种含有该化合物作为活性成分的制药组合物。这些化合物表现出对胰岛素分泌的促进活性和对高血糖的活性。因此，基于这些作用，包含这些化合物作为活性成分的制药组合物可用于治疗和/或预防胰岛素依赖性糖尿病（1型糖尿病）、非胰岛素依赖性糖尿病（2型糖尿病）、胰岛素抵抗性疾病、肥胖症等。
• New Acetyl Coenzyme A Carboxylase (ACC) Inhibitors And Uses In Treatments Of Obesity And Diabetes Mellitus - 087
  申请人：Blomberg David

  公开号：US20090306133A1

  公开（公告）日：2009-12-10

  The present invention relates to Acetyl Coenzyme A Carboxylase (ACC) inhibitors according to formula (I), or an enantiomer thereof, or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , R 3 , R 4 , R 5 , E, L, Z and n are as defined herein, to processes for preparing such compounds, to pharmaceutical compositions containing them, to the use of such inhibitors and to methods for their therapeutic use, particularly in the treatments of obesity and diabetes mellitus.

  本发明涉及Acetyl辅酶A羧化酶（ACC）抑制剂，其按照公式（I）或其对映体或其药学上可接受的盐，其中R1，R2，R3，R4，R5，E，L，Z和n的定义如本文所述，以及制备这种化合物的过程，包含它们的制药组合物，使用这种抑制剂的用途以及它们的治疗用途的方法，特别是在肥胖和糖尿病治疗中的应用。
• Aromatic-ring-fused pyrimidine derivative
  申请人：Astellas Pharma Inc.

  公开号：US07557112B2

  公开（公告）日：2009-07-07

  There are provided novel pyrimidine derivatives which has been fused with an aromatic heterocycle selected from thiophene, thiazole and pyridine or pharmaceutically acceptable salts thereof; and a pharmaceutical composition comprising said compound as an active ingredient. These compounds exhibit excellent promoting activity on insulin secretion and activity against hyperglycemia. Hence, the pharmaceutical compositions comprising such compounds as active ingredients, based on these actions, are useful for treating and/or preventing insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes), insulin-resistant diseases, obesity, and the like.

  提供了一种新颖的嘧啶衍生物，其与从噻吩、噻唑和吡啶中选择的芳香杂环或其药学上可接受的盐融合；以及包含该化合物作为活性成分的制药组合物。这些化合物表现出对胰岛素分泌的优异促进活性和对高血糖的活性。因此，基于这些作用，包含这些化合物作为活性成分的制药组合物可用于治疗和/或预防胰岛素依赖性糖尿病（1型糖尿病）、非胰岛素依赖性糖尿病（2型糖尿病）、胰岛素抵抗性疾病、肥胖症等。