6-methoxy-2,2-dimethyl-4-phenyl-chroman-4-carboxylic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 6-methoxy-2,2-dimethyl-4-phenyl-chroman-4-carboxylic acid
• 英文别名: 6-methoxy-2,2-dimethyl-4-phenyl-3H-chromene-4-carboxylic acid
• 化学式: C₁₉H₂₀O₄
• 分子量: 312.365
• InChiKey: NQYDWUYHUHIYSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-methoxy-2,2-dimethyl-4-phenyl-chroman-4-carboxylic acid 以70%的产率得到
  参考文献：
  名称：

  ZAUGG H. E.; LEONARD J. E.; DENET R. W.; ARENDSEN D. L., J. HETEROCYCL. CHEM. , 1974, 11, NO 5, 797-802

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 6-methoxy-2,2-dimethyl-4-phenyl-3H-chromene-4-carboxylate 以93%的产率得到
  参考文献：
  名称：

  ZAUGG H. E.; LEONARD J. E.; DENET R. W.; ARENDSEN D. L., J. HETEROCYCL. CHEM. , 1974, 11, NO 5, 797-802

  摘要：

  DOI：

文献信息

• Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
  申请人：AbbVie S.à.r.l.

  公开号：US20180244640A1

  公开（公告）日：2018-08-30

  The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

  本发明涉及化合物及其在囊性纤维化治疗中的应用，其生产方法，包含相同化合物的药物组合物，以及通过给予本发明化合物治疗囊性纤维化的方法。
• Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
  申请人：AbbVie S.à.r.l.

  公开号：US10428017B2

  公开（公告）日：2019-10-01

  The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

  本发明涉及治疗囊性纤维化的化合物及其用途、生产方法、包含本发明化合物的药物组合物，以及通过施用本发明化合物治疗囊性纤维化的方法。
• [EN] MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE<br/>[FR] MODULATEURS PROTÉIQUES DU RÉGULATEUR DE LA CONDUCTANCE TRANSMEMBRANAIRE DE LA FIBROSE KYSTIQUE ET PROCÉDÉS D'UTILISATION
  申请人：ABBVIE SARL

  公开号：WO2018154493A1

  公开（公告）日：2018-08-30

  The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention. Other embodiments of the invention include a pharmaceutical composition comprising a therapeutically effective amount of a compound of the present invention, or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier. In one aspect, the invention provides for compounds of Formula (I) (I) wherein A1 is selected from the group consisting of and R1, R2A, R2B, R2C, R2D, R3, R4, R5A, R5B, R5C, R5D, R6A, R6B, R6C, R6D, R7, R8, R9, R10, R11, R12, R13, and R14 are as defined herein.
• ZAUGG H. E.; LEONARD J. E.; DENET R. W.; ARENDSEN D. L., J. HETEROCYCL. CHEM. <JHTC-AD>, 1974, 11, NO 5, 797-802
  作者：ZAUGG H. E.、 LEONARD J. E.、 DENET R. W.、 ARENDSEN D. L.

  DOI：——

  日期：——