rhodamine B

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: rhodamine B
• 英文别名: leuco rhodamine B；[9-(2-Carboxyphenyl)-6-(diethylamino)-9,9a-dihydroxanthen-3-ylidene]-diethylazanium
• 化学式: C₂₈H₃₃N₂O₃
• 分子量: 445.582
• InChiKey: QRSIKPJDXBASMX-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  52.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  rhodamine B 在 sodium hydroxide 作用下， 以 乙酸乙酯 为溶剂， 以93%的产率得到溶剂红 49
  参考文献：
  名称：

  实用的合成路线到罗丹明染料。

  摘要：

  [反应：见正文]已经开发了一种合成功能化若丹明衍生物的有效方法。可以从廉价的前体制备数克量的这些水溶性荧光团，并在不使用色谱法的情况下进行纯化。通过后续反应已安装了一系列蛋白质反应性官能团，为生物分子修饰提供了材料。对于多色应用，已开发出一种固相纯化策略，以提供具有广泛光谱特性的罗丹明衍生物。

  DOI：

  10.1021/ol035135z
• 作为产物：
  描述：

  罗丹明B 在 sodium tetrahydroborate 作用下， 生成 rhodamine B
  参考文献：
  名称：

  Enhanced catalytic reductive hydrogenation of an organic dye by Ag decorated graphitic carbon nitride modified MCM-41

  摘要：

  使用 Ag 纳米粒子修饰的 gCN/MCM-41 将 RhB 脱色为白基形式的示意图。

  DOI：

  10.1039/d3ra05608b

文献信息

• DIARYLETHER-BASED FLUOROGENIC PROBES FOR DETECTION OF HYPOCHLOROUS ACID OR HYDROXYL RADICAL
  申请人：THE UNIVERSITY OF HONG KONG

  公开号：US20160312033A1

  公开（公告）日：2016-10-27

  Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening hypochlorous acid or hydroxyl radical. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining hypochlorous acid or hydroxyl radical in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of hypochlorous acid or hydroxyl radical in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening hypochlorous acid or hydroxyl radical or compounds that can increase or decrease the level of hypochlorous acid or hydroxyl radical in chemical and biological samples.

  本文提供了改进的荧光化合物和探针，可用作测量、检测和/或筛选次氯酸或羟基自由基的试剂。本发明的荧光化合物可以产生绿色、黄色、红色或远红色的荧光颜色。本文还提供了用于选择性染色活细胞线粒体中的次氯酸或羟基自由基的荧光化合物。本文还提供了可用于直接或间接测量化学样品和生物样品中次氯酸或羟基自由基的存在和/或数量的方法，如活体生物体中的细胞和组织。还提供了用于检测或筛选化学和生物样品中次氯酸或羟基自由基或能够增加或减少次氯酸或羟基自由基水平的化合物的高通量筛选方法。
• Diarylether-based fluorogenic probes for detection of hypochlorous acid or hydroxyl radical
  申请人：THE UNIVERSITY OF HONG KONG

  公开号：US10684294B2

  公开（公告）日：2020-06-16

  Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening hypochlorous acid or hydroxyl radical. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining hypochlorous acid or hydroxyl radical in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of hypochlorous acid or hydroxyl radical in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening hypochlorous acid or hydroxyl radical or compounds that can increase or decrease the level of hypochlorous acid or hydroxyl radical in chemical and biological samples.

  本发明提供了可用作测量、检测和/或筛选次氯酸或羟基自由基试剂的改进型致氟化合物和探针。本发明的致氟化合物可产生荧光颜色，如绿色、黄色、红色或远红色。本文还提供了用于选择性染色活细胞线粒体中次氯酸或羟自由基的含氟化合物。本文还提供了可用于直接或间接测量化学样品和生物样品（如活生物体的细胞和组织）中次氯酸或羟自由基的存在和/或数量的方法。本文还提供了高通量筛选方法，用于检测或筛选化学和生物样品中的次氯酸或羟自由基或可增加或减少次氯酸或羟自由基水平的化合物。
• SYNTHESIS OF CHEMICAL TAGS
  申请人：Saraf F. Ravi

  公开号：US20080108516A1

  公开（公告）日：2008-05-08

  A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one chemical moiety that prohibits recrystallization of the at least one denatured portion to which the at least one chemical moiety is attached is attached to at least one nucleotide in the at least one denatured portion of the at least one double stranded DNA molecule.
• US7846714B2
  申请人：——

  公开号：US7846714B2

  公开（公告）日：2010-12-07
• Practical Synthetic Route to Functionalized Rhodamine Dyes
  作者：Trung Nguyen、Matthew B. Francis

  DOI：10.1021/ol035135z

  日期：2003.9.1

  [reaction: see text] An efficient method for the synthesis of functionalized rhodamine derivatives has been developed. Multigram quantities of these water-soluble fluorophores can be prepared from inexpensive precursors and purified without the use of chromatography. A series of protein-reactive functional groups has been installed through subsequent reactions, providing materials for biomolecule modification

  [反应：见正文]已经开发了一种合成功能化若丹明衍生物的有效方法。可以从廉价的前体制备数克量的这些水溶性荧光团，并在不使用色谱法的情况下进行纯化。通过后续反应已安装了一系列蛋白质反应性官能团，为生物分子修饰提供了材料。对于多色应用，已开发出一种固相纯化策略，以提供具有广泛光谱特性的罗丹明衍生物。