2,2,2-Trifluoroethyl 4-methylpiperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2,2,2-Trifluoroethyl 4-methylpiperazine-1-carboxylate
• 化学式: C₈H₁₃F₃N₂O₂
• mdl: MFCD08246130
• 分子量: 226.2
• InChiKey: KJBZJNMUCIMURY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] CARM1 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE CARM1 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2016044604A1

  公开（公告）日：2016-03-24

  Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R1, R2a, R2b, R3 and Ring B are as defined herein, and Ring A is a group of Formula (A-i), (A-ii), or (A-iii): wherein R, R, R, R, and R are as defined herein. Compounds of the present invention are useful for inhibiting CARMl activity. Methods of using the compounds for treating CARMl -mediated disorders are also described.

  本文提供的是Formula (I)的化合物及其药用盐，以及药物组合物，其中R1、R2a、R2b、R3和环B如本文所定义，环A是Formula (A-i)、(A-ii)或(A-iii)的基团：其中R、R、R、R和R如本文所定义。本发明的化合物可用于抑制CARM1活性。还描述了利用这些化合物治疗CARM1介导的疾病的方法。
• CARM1 INHIBITORS AND USES THEREOF
  申请人：Epizyme, Inc.

  公开号：US20170305922A1

  公开（公告）日：2017-10-26

  Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R1, R2a, R2b, R3 and Ring B are as defined herein, and Ring A is a group of Formula (A-i), (A-ii), or (A-iii): wherein R, R, R, R, and R are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.