N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyloxy)propylamine

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyloxy)propylamine
• 英文别名: tert-butyl N-[3-[tert-butyl(diphenyl)silyl]oxypropyl]carbamate
• 化学式: C₂₄H₃₅NO₃Si
• 分子量: 413.632
• InChiKey: ZVFWZGQXDKLRGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.48
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyloxy)propylamine 在 1-氯乙基氯甲酸酯 作用下， 以 甲醇 为溶剂， 反应 5.5h， 以75%的产率得到N-(3-羟丙基)氨基甲酸叔丁酯
  参考文献：
  名称：

  Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol

  摘要：

  Fast and chemoselective desilylation of silyl-protected alcohols was achieved using a catalytic amount of 1-chloroethyl chloroformate in methanol. With a minimal amount of 1-chloroethyl chloroformate as the source for anhydrous HCl, extremely efficient cleavage of silyl ethers of primary and secondary alcohols was accomplished, and chemoselective deprotection of one silyl ether in the presence of another silyl or other acid-labile group was possible through controlling the amount of the chloroformate and reaction time. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.10.043
• 作为产物：
  描述：

  (3-Azido-propoxy)-tert-butyl-diphenyl-silane 以 甲苯 为溶剂， 反应 6.0h， 生成 N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyloxy)propylamine
  参考文献：
  名称：

  One-pot conversion of azides to Boc-protected amines with trimethylphosphine and Boc-ON

  摘要：

  Reaction of azides with trimethylphosphine followed by addition of 2-(tert-butoxycarbonyloxyimino)-2-phenyl- acetonitrile (Boc-ON) at -20 degrees C,and stirring at r.t. for 5 h affords the desired Boc-amines in 87-100% yields. Similar yields are obtained by mixing all components together (azide, Me3P, and Boc-ON) in toluene or THF. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02006-1

文献信息

• 一种阳离子脂质化合物及其制备方法和用途
  申请人：北京科兴中维生物技术有限公司

  公开号：CN117003808A

  公开（公告）日：2023-11-07

  本发明提供了一种阳离子脂质化合物及其制备方法和用途。所述阳离子脂质化合物具有式I所示结构。本发明提供的阳离子脂质化合物化学结构简单，易合成，可用于制备药物载体，特别是核酸药物载体。含有该阳离子脂质化合物的载药脂质纳米颗粒粒径小，粒径分布均一，对核酸药物具有良好的负载效果和递送效果。#imgabs0#
• TW2023/28149
  申请人：——

  公开号：——

  公开（公告）日：——
• Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol
  作者：Chang-Eun Yeom、Young Jong Kim、So Young Lee、Yong Je Shin、B. Moon Kim

  DOI：10.1016/j.tet.2005.10.043

  日期：2005.12

  Fast and chemoselective desilylation of silyl-protected alcohols was achieved using a catalytic amount of 1-chloroethyl chloroformate in methanol. With a minimal amount of 1-chloroethyl chloroformate as the source for anhydrous HCl, extremely efficient cleavage of silyl ethers of primary and secondary alcohols was accomplished, and chemoselective deprotection of one silyl ether in the presence of another silyl or other acid-labile group was possible through controlling the amount of the chloroformate and reaction time. (c) 2005 Elsevier Ltd. All rights reserved.
• One-pot conversion of azides to Boc-protected amines with trimethylphosphine and Boc-ON
  作者：Xavier Ariza、Fèlix Urpí、Carles Viladomat、Jaume Vilarrasa

  DOI：10.1016/s0040-4039(98)02006-1

  日期：1998.12

  Reaction of azides with trimethylphosphine followed by addition of 2-(tert-butoxycarbonyloxyimino)-2-phenyl- acetonitrile (Boc-ON) at -20 degrees C,and stirring at r.t. for 5 h affords the desired Boc-amines in 87-100% yields. Similar yields are obtained by mixing all components together (azide, Me3P, and Boc-ON) in toluene or THF. (C) 1998 Elsevier Science Ltd. All rights reserved.