(7CI)-(4-甲基-1-哌嗪)-脲 | 89582-54-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: (7CI)-(4-甲基-1-哌嗪)-脲
• 英文名称: 1-Methyl-4-ureido-piperazin
• 英文别名: (4-methyl-piperazin-1-yl)-urea；N-(4-Methylpiperazin-1-yl)urea；(4-methylpiperazin-1-yl)urea
• CAS: 89582-54-7
• 化学式: C₆H₁₄N₄O
• 分子量: 158.203
• InChiKey: VOUDNGYMQLJSJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  61.6
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933599090

文献信息

• [EN] UREA DERIVATIVES OF AMPHOTERICIN B DERIVED FROM SECONDARY AMINES<br/>[FR] DÉRIVÉS D'URÉE DE L'AMPHOTÉRICINE B DÉRIVÉE D'AMINES SECONDAIRES
  申请人：UNIV ILLINOIS

  公开号：WO2016112243A1

  公开（公告）日：2016-07-14

  Provided are certain urea derivatives of amphotericin B (AmB) having improved therapeutic index compared to AmB. The compounds of the invention are less toxic than AmB and are useful to treat fungal infections. In certain embodiments the urea derivative of AmB is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof: wherein, independently for each occurrence: R represents methyl, ethyl, propyl, or isopropyl; R' represents methyl, ethyl, propyl, or isopropyl; or R and R', taken together with the nitrogen atom to which they are attached, represent a radical of a cyclic secondary amine. Also provided are methods for making the urea derivatives of AmB.

  提供了与两性霉素B（AmB）相比具有改善的治疗指数的某些尿素衍生物。本发明的化合物比AmB毒性更小，并且可用于治疗真菌感染。在某些实施例中，AmB的尿素衍生物是由以下式（I）表示的化合物或其药用可接受的盐：其中，对于每次出现独立地：R代表甲基、乙基、丙基或异丙基；R'代表甲基、乙基、丙基或异丙基；或R和R'与它们连接的氮原子一起表示环状二级胺的基团。还提供了制备AmB的尿素衍生物的方法。
• [EN] ARYLAMINO PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF<br/>[FR] DÉRIVÉS ARYLAMINÉS DE PURINE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION PHARMACEUTIQUE
  申请人：SI CHUAN UNIVERSITY

  公开号：WO2011147066A1

  公开（公告）日：2011-12-01

  Arylamino purine derivatives represented by formula I and their preparation method are disclosed, wherein each substituent is defined as in the description. The derivatives have an inhibitory effect on non-small cell lung cancer with deletion mutation of exon 19 or L858R point mutation of exon 21 in epidermal growth factor receptor (EGFR).

  本发明揭示了由公式I表示的芳基氨基嘌呤衍生物及其制备方法，其中每个取代基在描述中有定义。这些衍生物对于表皮生长因子受体（EGFR）的外显子19缺失突变或外显子21的L858R点突变的非小细胞肺癌具有抑制作用。
• Substituted Biphenyl Derivative
  申请人：Kurata Hitoshi

  公开号：US20070275968A1

  公开（公告）日：2007-11-29

  The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: wherein R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.

  本发明涉及一种具有优异的胶原合成抑制活性的双芳基衍生物或其药学上可接受的盐。一种具有以下通式（I）所表示的结构或其药学上可接受的盐的双芳基衍生物：其中，R1代表一个C6-C10芳基基团，该基团被一个或三个独立选择的基团所取代，所述基团由公式R-L-、二（C1-C6烷基）氨基基团、二（C1-C6烷基）氨基磺酰基团、羟胺基甲酰基团、卤素原子等组成；R代表C1-C6烷基基团等；L代表磺酰基、氨基磺酰基或磺酰胺基等基团；R2代表氢原子等；A代表由公式（II）、（III）或（IV）所定义的基团；R3代表C1-C6烷基基团等；R4代表C1-C6烷基基团等。
• Arylamino Purine Derivatives, Preparation Method and Pharmaceutical Use Thereof
  申请人：Yang Shengyong

  公开号：US20130203986A1

  公开（公告）日：2013-08-08

  Arylamino purine derivatives represented by formula I and their preparation method are disclosed, wherein each substituent is defined as in the description. The derivatives have an inhibitory effect on non-small cell lung cancer with deletion mutation of exon 19 or L858R point mutation of exon 21 in epidermal growth factor receptor (EGFR).

  公开了由公式I所代表的芳基氨基嘌呤衍生物及其制备方法，其中每个取代基在说明书中有定义。这些衍生物对于表皮生长因子受体（EGFR）的外显子19缺失突变或外显子21的L858R点突变所致的非小细胞肺癌具有抑制作用。
• SUBSTITUTED BIPHENYL DERIVATIVE
  申请人：Sankyo Company, Limited

  公开号：EP1798229A1

  公开（公告）日：2007-06-20

  The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C6-C10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C1-C6 alkyl)amino group, a di-(C1-C6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C1-C6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R3 represents a C1-C6 alkyl group, and so on; and R4 represents a C1-C6 alkyl group, and so on.

  本发明涉及一种具有优异胶原合成抑制活性的生物芳基衍生物或其药理学上可接受的盐。一种具有下通式（I）所代表结构的生物芳基衍生物或其药理学上可接受的盐： 其中 R1代表C6-C10芳基，该芳基被一至三个各自独立地选自式R-L-定义的基团、二-(C1-C6烷基)氨基、二-(C1-C6烷基)氨基磺酰基、羟基氨基羰基和卤原子等组成的组取代；R 代表 C1-C6 烷基，以此类推；L 代表磺酰基、氨磺酰基或磺酰氨基，以此类推；R2 代表氢原子，以此类推；A 代表式（II）、（III）或（IV）定义的基团；R3 代表 C1-C6 烷基，以此类推；R4 代表 C1-C6 烷基，以此类推。