1-[4-(2-ethylphenyl)piperazin-1-yl]-3-[2-oxopyrrolidin-1-yl] propane | 223525-85-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[4-(2-ethylphenyl)piperazin-1-yl]-3-[2-oxopyrrolidin-1-yl] propane
• 英文别名: 1-[3-[4-(2-Ethylphenyl)piperazin-1-yl]propyl]pyrrolidin-2-one
• CAS: 223525-85-7
• 化学式: C₁₉H₂₉N₃O
• 分子量: 315.459
• InChiKey: RKXKPNAHCUQGBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  26.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• A proces for the synthesis of 1-(4-Arylpiperazine-1-y1)-3-(2-oxypyrrolidin/piperidin-1-y1) propanes as therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders
  申请人：Council of Scientific and Industrial Research

  公开号：EP0913397A1

  公开（公告）日：1999-05-06

  A process of preparing novel compounds of formula 1 Wherein Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl, n=1 or n=2; said compounds are used as potential therapeutic agents for hypertension, ischemic, cardiovascular and other adrenergic receptors related disorders, said process comprising condensing 2-pyrrolidone of formula 2 (n=1) or 2-piperidone of formula 2 (n=2) with 1-[4-substituted arylpiperazin-1-yl]-3-chloropropanes of formula 5 where Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl in the presence of a base and organic solvent at a temperature ranging from 120-150°C for a period varying between 90 min. to 14 hrs. to produce the corresponding 1-[4-substituted arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes of formula 1.

  一种制备式 1 新型化合物的工艺 其中 Ar 代表被卤代、烷氧基、烷基或杂芳基等基团取代的苯基环，n=1 或 n=2；所述化合物可用作高血压、缺血、心血管和其他肾上腺素能受体相关疾病的潜在治疗剂，所述工艺包括将式 2 的 2-吡咯烷酮（n=1）或式 2 的 2-哌啶酮（n=2）与式 5 的 1-[4-取代芳基哌嗪-1-基]-3-氯丙烷缩合，其中 Ar 代表被卤代、烷氧基、烷基或杂芳基等基团取代的苯基环、在碱和有机溶剂存在下，在 120-150°C 的温度范围内，经过 90 分钟至 14 小时，制得式 5 所示的[4-取代芳基哌嗪-1-基]-3-氯丙烷。至 14 小时，生成相应的式 1 的 1-[4-取代芳基哌嗪-1-基]-3-[2-氧代吡咯烷/哌啶-1-基]丙烷。
• 1-(4-Arylpiperazine-1-y1)-3-(2-oxopyrrolidin/piperidin-1-y1) propanes as therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders
  申请人：Council of Scientific & Industrial Research

  公开号：EP0911330B1

  公开（公告）日：2007-12-12
• A proces for the synthesis of 1-(4-Arylpiperazine-1-y1)-3-(2-oxypyrrolidin/piperidin-1-yl)propanes as therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：EP0913397B1

  公开（公告）日：2006-07-05
• US6084097A
  申请人：——

  公开号：US6084097A

  公开（公告）日：2000-07-04
• US6150367A
  申请人：——

  公开号：US6150367A

  公开（公告）日：2000-11-21