5-{2-(4-(4-ethylpiperazin-1-yl)phenyl)pyridin-4-yl}-4-(6-methyl-pyridin-2-yl)-1,3-thiazol-2-ylamine | 656257-90-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-{2-(4-(4-ethylpiperazin-1-yl)phenyl)pyridin-4-yl}-4-(6-methyl-pyridin-2-yl)-1,3-thiazol-2-ylamine
• 英文别名: 5-[2-[4-(4-Ethylpiperazin-1-yl)phenyl]pyridin-4-yl]-4-(6-methylpyridin-2-yl)-1,3-thiazol-2-amine
• CAS: 656257-90-8
• 化学式: C₂₆H₂₈N₆S
• 分子量: 456.615
• InChiKey: FXAXTKVHVOPEFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  99.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Compounds
  申请人：Dodic Nerina

  公开号：US20060004051A1

  公开（公告）日：2006-01-05

  The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及一种新型的氨基噻唑衍生物，该衍生物是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是抑制TGF-β类型I或类激活素样激酶（“ALK”）-5受体对smad2或smad3的磷酸化，以及该衍生物的制备方法和在医学上的应用，具体地用于治疗和预防由该通路介导的疾病状态。
• COMPOUNDS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1554275A2

  公开（公告）日：2005-07-20
• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004013134A2

  公开（公告）日：2004-02-12

  The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, ('TGF')-ß signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ('ALK')-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.