5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-N-(2-methoxyethyl)-1-benzofuran-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-N-(2-methoxyethyl)-1-benzofuran-2-carboxamide
• 化学式: C₂₉H₃₃N₅O₃
• 分子量: 499.6
• InChiKey: MYAKFFVIELATHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  97.5
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Substituted benzofuran-2-carboxamides derivatives
  申请人：Dorsch Dieter

  公开号：US20050075269A1

  公开（公告）日：2005-04-07

  Compounds of the formula (I), in which D, R 1 , R 2 and n are defined in Claim 1 , are potent 5-HT 1A agonists and 5-HT reuptake inhibitors and are suitable for the treatment of depression, anxiety states, panic attacks, obsessive-compulsive disorders, psychiatric illnesses, cerebral infarction, cerebral ischaemia, tension states, side-effects in the treatment of high blood pressure, for the prophylaxis and therapy of cerebral illnesses, acromegaly, hypogonadism, secondary amenorrhoea, premenstrual syndrome, undesired puerperal lactation, pain, sleep disorders, narcolepsy, bipolar illnesses, mania, dementia, addiction illnesses, sexual dysfunction, eating disorders, obesity or fibromyalgia.

  公式(I)的化合物，其中D、R1、R2和n在权利要求1中定义，是有效的5-HT1A激动剂和5-HT再摄取抑制剂，适用于治疗抑郁症、焦虑状态、惊恐发作、强迫症、精神疾病、脑梗塞、脑缺血、紧张状态、高血压治疗的副作用、脑疾病的预防和治疗、肢端肥大症、性腺功能减退症、继发性闭经、经前综合征、不良产后泌乳、疼痛、睡眠障碍、嗜睡症、双相情感障碍、躁狂症、痴呆症、成瘾性疾病、性功能障碍、进食障碍、肥胖症或纤维肌痛。
• SUBSTITUTED BENZOFURAN-2-CARBOXAMIDES DERIVATIVES
  申请人：MERCK PATENT GmbH

  公开号：EP1368346A1

  公开（公告）日：2003-12-10
• US7244846B2
  申请人：——

  公开号：US7244846B2

  公开（公告）日：2007-07-17
• [EN] SUBSTITUTED BENZOFURAN-2-CARBOXAMIDES DERIVATIVES<br/>[FR] DERIVES DE BENZOFURAN-2-CARBOXAMIDES SUBSTITUES
  申请人：MERCK PATENT GMBH

  公开号：WO2002083666A1

  公开（公告）日：2002-10-24

  Compounds of the formula (I), in which D, R1, R2 and n are defined in Claim 1, are potent 5-HT¿1A? agonists and 5-HT reuptake inhibitors and are suitable for the treatment of depression, anxiety states, panic attacks, obsessive-compulsive disorders, psychiatric illnesses, cerebral infarction, cerebral ischaemia, tension states, side-effects in the treatment of high blood pressure, for the prophylaxis and therapy of cerebral illnesses, acromegaly, hypogonadism, secondary amenorrhoea, premenstrual syndrome, undesired puerperal lactation, pain, sleep disorders, narcolepsy, bipolar illnesses, mania, dementia, addiction illnesses, sexual dysfunction, eating disorders, obesity or fibromyalgia.