2-[4-(Hydroxymethyl)piperazin-1-yl]ethanesulfonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(Hydroxymethyl)piperazin-1-yl]ethanesulfonic acid
• 化学式: C₇H₁₆N₂O₄S
• 分子量: 224.28
• InChiKey: JTJUCMWDAIRSQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89.5
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Agglutination immunoassay
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0503454A1

  公开（公告）日：1992-09-16

  A method for enhancing the reactivity of microparticle based immunoassays has been developed using polyvinylpyrrolidones (PVP). Microparticle aggregation reactions are accelerated resulting in increased standard curve dynamics and improved sensitivity.

  利用聚乙烯吡咯烷酮（PVP）开发了一种增强微颗粒免疫测定反应性的方法。该方法可加速微粒子的聚集反应，从而提高标准曲线的动态性和灵敏度。
• Isolation of nucleic acids on surfaces
  申请人：Gauch Simone

  公开号：US20050244882A1

  公开（公告）日：2005-11-03

  New processes and equipment to isolate and purify nucleic acids on surfaces are provided. The invention focuses on processes which use surfaces, for example, porous membranes, on which the nucleic acids are immobilized in a simple manner from the sample containing the nucleic acids and can be released again by way of simple procedural steps, whereby the simple performance of the process according to the invention makes it possible to perform the processes specifically in a fully automatic manner. An additional aspect of the present invention focuses on binding the nucleic acids to an immobile phase, especially to a membrane, in such a way and manner, that they can be released without difficulty during an additional reaction stage from this phase and, if desired, can be used in other applications, such as restriction digestion, RT, PCR or RT-PCR, or in any of the suitable analyses or enzyme reactions mentioned in the disclosure. Special isolation devices are provided that can be used to carry out the processes according to the invention.

  本发明提供了在表面上分离和纯化核酸的新工艺和设备。本发明的重点是使用表面（例如多孔膜）的工艺，核酸以简单的方式从含有核酸的样品中固定在这些表面上，并可通过简单的程序步骤再次释放出来，因此，根据本发明的工艺的简单执行使得以全自动的方式具体执行工艺成为可能。本发明的另一个方面是将核酸与不流动相，特别是与膜结合，结合的方式和方法可以使核酸在额外的反应阶段从该相中顺利释放，如果需要，还可以用于其他应用，如限制性消化、RT、PCR 或 RT-PCR，或用于本公开中提到的任何合适的分析或酶反应。本发明提供的特殊分离装置可用于实施本发明的工艺。
• ERYTHROCYTES AND THROMBO-ERYTHROCYTES AS TARGET SPECIFIC AGENTS
  申请人：THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

  公开号：EP0558645A1

  公开（公告）日：1993-09-08
• HYDROGEL-FORMING COMPOSITION FOR CONTROLLED RELEASED
  申请人：Vrije Universiteit Brussel

  公开号：EP3419642A1

  公开（公告）日：2019-01-02
• HYDROGEL-FORMING COMPOSITION FOR CONTROLLED RELEASE
  申请人：Vrije Universiteit Brussel

  公开号：US20200246472A1

  公开（公告）日：2020-08-06

  The present invention provides peptide hydrogelators capable of forming hydrogels as carriers of active ingredients and acting as sustained or controlled release drug delivery systems.