(R)-N-[2-Chloro-3-(4-acetylpiperazin-1-yl)-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide | 329926-36-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (R)-N-[2-Chloro-3-(4-acetylpiperazin-1-yl)-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
• 英文别名: (R)-N-[2-chloro-3-(1-(4-acetyl)piperazinyl)-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide；(2R)-N-[3-(4-acetylpiperazin-1-yl)-2-chloro-4-propan-2-ylsulfonylphenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
• CAS: 329926-36-5
• 化学式: C₁₉H₂₅ClF₃N₃O₅S
• 分子量: 499.939
• InChiKey: GPKJFSJOBJNXDQ-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• SUBSTITUTED N-PHENYL 2-HYDROXY-2-METHYL-3,3,3-TRIFLUOROPROPANAMIDE DERIVATIVES WHICH ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY
  申请人：AstraZeneca AB

  公开号：EP1214296B1

  公开（公告）日：2004-03-24
• US6689909B1
  申请人：——

  公开号：US6689909B1

  公开（公告）日：2004-02-10
• [EN] SUBSTITUTED N-PHENYL 2-HYDROXY-2-METHYL-3,3,3-TRIFLUOROPROPANAMIDE DERIVATIVES WHICH ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY<br/>[FR] DERIVES DE N-PHENYL 2-HYDROXY-2-METHYL-3,3,3-TRIFLUOROPROPANAMIDE SUBSTITUES DESTINES A AUGMENTER L'ACTIVITE DE PYRUVATE DESHYDROGENASE
  申请人：ASTRAZENECA AB

  公开号：WO2001017956A1

  公开（公告）日：2001-03-15

  A compound of formula (I) wherein: n is 1 or 2; R1 is chloro, fluoro, bromo, methyl or methoxy; R2 is as defined within; R3 is as defined within; and R4 is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.