毒理性
锑三磺是一种固体，呈灰色或红橙色。它被用于烟火制造，也被用于制造红宝石玻璃、火柴、炸药以及在油漆中作为颜料。在一个人体研究中，对在一个使用锑三磺的工厂中的工人进行了研究，重点是心血管状况。在研究之前，有125名接触锑三磺8个月至2年的工人中突然死亡了6人。死亡怀疑是由心脏病引起的。在研究的工人中，113人中有14人的血压大于140/90毫米汞柱，75人中有37人的心电图出现了显著变化，主要是T波。在111名接触者中发现了7例溃疡（每1000人中有63例），而整个工厂人群中每1000人有15例。尽管停止使用锑三磺，但665名工人中有12人的心电图变化持续存在。在动物研究中，家兔在接触27.8毫克/立方米锑三磺五天后，观察到肝脏和肾小管上皮的退行性变化。大鼠通过吸入3.1毫克/立方米锑三磺六周后，心电图发生了变化，特别是T波变平。在尸检中，发现心脏扩张，有退行性变化的迹象；肺部的局部出血和充血被认为是心力衰竭的继发症状。两只狗在接触5.6毫克/立方米十周后观察到心脏毒性变化。连续口服给药8周和12周对生长大鼠的肾脏结构和功能有毒害作用。
IDENTIFICATION AND USE: Antimony trisulfide is a solid, grey or red-orange. It is used in pyrotechnics, as well as in the manufacture of ruby glass, matches, explosives, and as a pigment in paints. HUMAN STUDIES: Workmen in a plant where antimony trisulfide was used were studied, focusing on cardiovascular status. Prior to the study there had been six sudden deaths in a group of 125 workers exposed to antimony for 8 months to 2 years. The deaths were suspected to be due to heart disease. In the workers studied, 14 of 113 had blood pressures that were >140/90 mm Hg, and 37 of 75 showed significant changes in their EKGs, mostly the T-wave. Ulcers were detected in 7 of 111 exposed persons (63 per 1,000) as compared with 15 per 1,000 in the total plant population. Although use of antimony trisulfide was discontinued, EKG changes persisted in 12 of 665 workers. ANIMAL STUDIES: Degenerative changes in the liver and in the tubular epithelium of the kidney were observed in rabbits exposed to 27.8 mg/cu m antimony trisulfide for five days. Rats exposed to 3.1 mg/cu m antimony trisulfide by inhalation for six weeks developed electrocardiographic changes, notably with flattened T-waves. On autopsy, the heart was found to be dilated, with signs of degenerative changes; focal hemorrhage and congestion in the lungs were considered to be secondary to heart failure. Cardiotoxic changes were observed in two dogs exposed to 5.6 mg/cu m for ten weeks. Continuous oral administration of antimony for 8 and 12 weeks had toxic effect on the structure and function of the kidney in growing rat.
来源:Hazardous Substances Data Bank (HSDB)
