4-bromo-N-[4-(4-methyl-piperazin-1-yl)-quinolin-6-yl]benzenesulfonamide | 771466-14-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-bromo-N-[4-(4-methyl-piperazin-1-yl)-quinolin-6-yl]benzenesulfonamide
• 英文别名: 4-bromo-N-[4-(4-methylpiperazin-1-yl)quinolin-6-yl]benzenesulfonamide
• CAS: 771466-14-9
• 化学式: C₂₀H₂₁BrN₄O₂S
• 分子量: 461.382
• InChiKey: FVDXPCISEIGYMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Use
  申请人：——

  公开号：US20030166663A1

  公开（公告）日：2003-09-04

  The invention provides methods of treatment or prophylaxis of obesity, or methods of treatment for the reduction of food intake, comprising administering to a patient in need of such treatment a therapeutically effective amount of a sulfonamide compound of Formula I: 1 wherein the substituents are as described in the specification.

  本发明提供了治疗或预防肥胖症的方法，或减少食物摄入量的治疗方法，包括向需要这种治疗的患者施用治疗有效量的式 I 的磺酰胺化合物： 1 其中取代基如说明书所述。
• SULFONAMIDE DERIVATIVES
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1228066A2

  公开（公告）日：2002-08-07
• USE OF SULFONAMIDE DERIVATIVES IN THE TREATMENT OF OBESITY OR FOR THE REDUCTION OF FOOD INTAKE
  申请人：BIOVITRUM AB

  公开号：EP1450806A1

  公开（公告）日：2004-09-01
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2001032646A2

  公开（公告）日：2001-05-10

  Novel sulfonamide compounds having CNS activity, processes for their preparation, to compositions containing the same and their use as medicaments.
• [EN] USE OF SULFONAMIDE DERIVATIVES IN THE TREATMENT OF OBESITY OR FOR THE REDUCTION OF FOOD INTAKE<br/>[FR] UTILISATION DE DERIVES SULFONAMIDE DANS LE TRAITEMENT DE L'OBESITE OU POUR LA REDUCTION DE PRISE D'ALIMENTS
  申请人：BIOVITRUM AB

  公开号：WO2003039547A1

  公开（公告）日：2003-05-15

  The invention provides a method of treatment or prophylaxis of obesity or for the reduction of food intake, comprising administering to a patient in need of such treatment a therapeutically effective amount of a sulfonamide compound of formula (I). Wherein the substituents are described in the specification.