[2-[1-(4,6-difluoro-1H-benzimidazol-2-yl)ethyl]-3-methylbenzimidazol-5-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [2-[1-(4,6-difluoro-1H-benzimidazol-2-yl)ethyl]-3-methylbenzimidazol-5-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone
• 化学式: C₂₈H₂₅F₃N₆O
• 分子量: 518.5
• InChiKey: DCKUFCPZCGCBLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• NEW BIS-BENZIMIDAZOLES
  申请人：Bayer Aktiengesellschaft

  公开号：EP1117651A1

  公开（公告）日：2001-07-25
• [EN] NEW BIS-BENZIMIDAZOLES<br/>[FR] NOUVEAUX BIS-BENZIMIDAZOLES
  申请人：BAYER YAKUHIN LTD

  公开号：WO2000020401A1

  公开（公告）日：2000-04-13

  Bis-benzimidazole compounds of general formula (I) in which R?1, R2, R3 and R4¿ are hydrogen, hydroxy or halogen, R?5 and R8¿ are hydrogen, or (C¿1?-C4)-alkyl,R?6 and R7¿ are hydrogen, or (C¿1?-C6)-alkyl, hydroxy, halogen, or (C1-C6)-alkoxy, R?9, R10 and R11¿ are hydrogen, halogen, nitro, cyano or trifluoromethyl, and A is a non-aromatic 5-7-membered N-heterocycle, etc, process for their preparation and their use for treating diseases associated with tryptase activity including allergic, inflammatory and related immunological diseases, in particular asthma, allergic rhinitis, allergic conjunctivitis and allergic dermatitis.