5-bromo-2-(4-methoxyphenyl)-3-piperazin-1-yl-1H-pyrrolo[2,3-b]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-bromo-2-(4-methoxyphenyl)-3-piperazin-1-yl-1H-pyrrolo[2,3-b]pyridine
• 化学式: C₁₈H₁₉BrN₄O
• 分子量: 387.3
• InChiKey: PRWQLAXBDGCHND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  53.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Substituted pyrrolopyridines
  申请人：Nielsen Aadal Peter

  公开号：US20050215582A1

  公开（公告）日：2005-09-29

  There are provided novel compounds of formula (I) wherein R 1 , R 2 and R 3 are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the kinase Itk.

  提供了式(I)的新化合物，其中R1，R2和R3如规范中所定义，并且其药学上可接受的盐；以及它们的制备方法，包含它们的组合物和它们在治疗中的用途。这些化合物是激酶Itk的抑制剂。
• SUBSTITUTED PYRROLOPYRIDINES
  申请人：AstraZeneca AB

  公开号：EP1539758A1

  公开（公告）日：2005-06-15
• [EN] SUBSTITUTED PYRROLOPYRIDINES<br/>[FR] PYRROLOPYRIDINES SUBSTITUEES
  申请人：ASTRAZENECA AB

  公开号：WO2004016610A1

  公开（公告）日：2004-02-26

  There are provided novel compounds of formula (I) wherein R1, R2 and R3 are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the kinase Itk.