1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-(4-(4-(pyridin-4-yl)piperazin-1-yl)phenyl)urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-(4-(4-(pyridin-4-yl)piperazin-1-yl)phenyl)urea
• 英文别名: 1-[2-oxo-5-(2-phenylethyl)-1-propyl-3H-1,4-benzodiazepin-3-yl]-3-[4-(4-pyridin-4-ylpiperazin-1-yl)phenyl]urea
• 化学式: C₃₆H₃₉N₇O₂
• 分子量: 601.7
• InChiKey: VLIFIGMDNURHMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  45
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• INDOLE DERIVATIVES
  申请人：Beke Gyula

  公开号：US20130217702A1

  公开（公告）日：2013-08-22

  The present invention relates to the indole derivatives of formula (I), wherein R 1 -R 6 and X are defined in the claims and optical antipodes or racemates and/or salts thereof which are selective antagonists of bradykinin B1 to process for producing these compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及式(I)的吲哚衍生物，其中R1-R6和X在权利要求中定义，并且其光学对映体或消旋体和/或盐是布雷金肽B1的选择性拮抗剂，用于制备这些化合物的方法，含有它们的药理学组合物以及它们在治疗或预防疼痛和炎症症状中的用途。
• [EN] INDOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'INDOLE
  申请人：RICHTER GEDEON NYRT

  公开号：WO2012059776A1

  公开（公告）日：2012-05-10

  The present invention relates to the indole derivatives of formula (I), wherein R1- R6 and X are defined in the claims and optical antipodes or racemates and/or salts thereof which are selective antagonists of bradykinin B1 to process for producing these compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及式(I)的吲哒衍生物，其中R1-R6和X在权利要求中定义，并且其光学对映体或消旋体和/或盐是布雷金肽B1的选择性拮抗剂，用于生产这些化合物的方法，含有它们的药物组合物以及它们在治疗或预防疼痛和炎症状况中的使用。
• NON-PEPTIDE DERIVATIVES AS BRADYKININ B1 ANTAGONISTS
  申请人：Vago Istvan

  公开号：US20100298299A1

  公开（公告）日：2010-11-25

  The present invention relates to new non-peptide derivatives of formula (I), wherein R 1 -R 5 , Q and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及公式（I）的新非肽衍生物，其中R1-R5、Q和Z如权利要求中所定义，并且其光学对映体或外消旋体和/或盐和/或水合物和/或溶剂化合物，这些衍生物是布雷肽B1的选择性拮抗剂，以及用于制备这些化合物的方法，含有它们的药物组合物，以及它们在治疗或预防疼痛和炎症症状中的用途。
• PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS
  申请人：Beke Gyula

  公开号：US20100105686A1

  公开（公告）日：2010-04-29

  The present invention relates to new sulfonamide derivatives of formula (I) wherein R 1 -R 8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these same compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及式(I)的新磺酰胺衍生物，其中R1-R8和Z如权利要求中所定义，以及其光学对映体或外消旋体和/或盐和/或水合物和/或溶剂化物，它们是布雷地酮B1的选择性拮抗剂，用于制备这些化合物的方法、包含它们的药理学组合物以及它们在治疗或预防疼痛和炎症状况中的应用。
• NEW BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS
  申请人：Vago Istvan

  公开号：US20100087423A1

  公开（公告）日：2010-04-08

  The present invention relates to new phenylsulfamoyl benzamide derivatives of formula (I) wherein R 1 -R 5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及新的苯磺酰苯酰胺衍生物，其化学式为(I)，其中R1-R5和Z如权利要求中所定义，以及其光学对映体或外消旋体和/或盐和/或水合物和/或溶剂合物，它们是缓激肽B1选择性拮抗剂，用于制备这些化合物的过程，包含它们的药理学组合物以及在治疗或预防疼痛和炎症症状中的应用。