5-Nitroso-4-(4-nitrosopiperazin-1-yl)-2,6-dipyrrolidin-1-ylpyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-Nitroso-4-(4-nitrosopiperazin-1-yl)-2,6-dipyrrolidin-1-ylpyrimidine
• 化学式: C₁₆H₂₄N₈O₂
• 分子量: 360.41
• InChiKey: OKFFBSDCIYWNHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  97.6
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• Nitroso compounds to treat ischemia
  申请人：Toledo H. Luis

  公开号：US20050113573A1

  公开（公告）日：2005-05-26

  The invention includes piperazinyl pyrimidinyl nitroso compounds of the formula (II) and N-Nitrosometoprolol and pharmaceutically acceptable salts thereof which are useful in treating one or more of the following ischemic diseases, coronary heart disease, stroke, hemorrhagic shock, peripheral vascular disease (of both the upper and lower extremities), abdominal vascular insufficiency and transplant related surgery.

  该发明涉及式（II）的哌嗪基嘧啶基亚硝基化合物以及N-亚硝基美托洛尔和其药学上可接受的盐，其可用于治疗以下一种或多种缺血性疾病：冠心病、中风、出血性休克、上下肢周围血管疾病、腹部血管不足和移植相关手术。
• [EN] NITROSO COMPOUNDS TO TREAT ISCHEMIA<br/>[FR] COMPOSES NITROSO POUR TRAITER L'ISCHEMIE
  申请人：HESSLER EDWARD J

  公开号：WO2004050639A2

  公开（公告）日：2004-06-17

  The invention includes piperazinyl pyrimidinyl nitroso compounds of the formula (II) and N-Nitrosometoprolol and pharmaceutically acceptable salts thereof which are useful in treating one or more of the following ischemic diseases, coronary heart disease, stroke, hemorrhagic shock, peripheral vascular disease (of both the upper and lower extremities), abdominal vascular insufficiency and transplant related surgery.