1-(1-Benzofuran-5-yl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(1-Benzofuran-5-yl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-one
• 化学式: C₂₂H₂₄N₂O₃
• 分子量: 364.4
• InChiKey: FZYBNIMVYAGUCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  45.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Neurodegenerative protein aggregation inhibition methods and compounds
  申请人：Graef A. Isabella

  公开号：US20050209173A1

  公开（公告）日：2005-09-22

  Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting element for binding to the target proteins linked to a second domain or recruiting element that binds to an aggregation inhibiting protein, e.g. a prolyl isomerase. By associating the aggregating forming proteins or neuronal cells under conditions where aggregating proteins are produced with the compound and the aggregation inhibiting protein, aggregation is reduced. The subject agents can be used in assays, investigating the etiology of the neuronal diseases and for prophylaxis and therapy.

  提供了减少与神经毒性相关的神经退行性蛋白或其他蛋白聚集的方法和组合物。这些化合物包括用于与靶蛋白结合的第一结构域或靶向元件，该结构域或招募元件与与聚集抑制蛋白（如脯氨酰异构酶）结合的第二结构域或招募元件相连。在产生聚集蛋白的条件下，将聚集形成蛋白或神经元细胞与化合物和聚集抑制蛋白结合，可减少聚集。上述制剂可用于检测、研究神经元疾病的病因以及预防和治疗。
• NEURODEGENERATIVE PROTEIN AGGREGATION INHIBITION METHODS AND COMPOUNDS
  申请人：Graef Isabella A.

  公开号：US20080182792A1

  公开（公告）日：2008-07-31

  Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting element for binding to the target proteins linked to a second domain or recruiting element that binds to an aggregation inhibiting protein, e.g. a prolyl isomerase. By associating the aggregating forming proteins or neuronal cells under conditions where aggregating proteins are produced with the compound and the aggregation inhibiting protein, aggregation is reduced. The subject agents can be used in assays, investigating the etiology of the neuronal diseases and for prophylaxis and therapy.
• Neurodegenerative Protein Aggregation Inhibition Methods and Compounds
  申请人：Graef Isabella A.

  公开号：US20110160246A1

  公开（公告）日：2011-06-30

  Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting element for binding to the target proteins linked to a second domain or recruiting element that binds to an aggregation inhibiting protein, e.g. a prolyl isomerase. By associating the aggregating forming proteins or neuronal cells under conditions where aggregating proteins are produced with the compound and the aggregation inhibiting protein, aggregation is reduced. The subject agents can be used in assays, investigating the etiology of the neuronal diseases and for prophylaxis and therapy.
• US7485706B2
  申请人：——

  公开号：US7485706B2

  公开（公告）日：2009-02-03
• US7923230B2
  申请人：——

  公开号：US7923230B2

  公开（公告）日：2011-04-12