(Z)-5-(苯并[c][1,2,5]噁二唑-5-基亚甲基)噻唑烷-2,4-二酮 | 648450-69-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 中文名称: (Z)-5-(苯并[c][1,2,5]噁二唑-5-基亚甲基)噻唑烷-2,4-二酮
• 英文名称: 5-[(2,1,3-Benzoxadiazol-5-yl)methylidene]-1,3-thiazolidine-2,4-dione
• 英文别名: 5-(2,1,3-benzoxadiazol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione
• CAS: 648450-69-5
• 化学式: C₁₀H₅N₃O₃S
• 分子量: 247.23
• InChiKey: BNFROMQPTMIJEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES<br/>[FR] DERIVES DE BENZENE A FUSION AZOLIDINONE-VINYLE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2004007491A1

  公开（公告）日：2004-01-22

  The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R1 , R2 and n are as described in the description.

  本发明涉及式(I)的噁唑烷二酮-乙烯融合苯衍生物，用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、细菌或病毒感染、肾脏疾病、血小板聚集、癌症、移植排斥或肺部损伤。式(I)中，A、X、Y、Z、R1、R2和n如描述中所述。
• [EN] USE OF COMPOUNDS FOR INCREASING SPERMATOZOA MOTILITY<br/>[FR] UTILISATION DE COMPOSES POUR ACCROITRE LA MOTILITE DES SPERMATOZOIDES
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2004006916A1

  公开（公告）日：2004-01-22

  The invention relates to a process for the improvement of spermatozoa fertilization activity, in particular for the increase of spermatozoa motility, by using a compound of formula (I). The invention further relates to uses and methods of compounds of formula (I) in infertility and assisted reproduction techniques (ART) as well as to a medium for storage and/or transportation of spermatozoa comprising said P13K inhibitors.

  本发明涉及一种通过使用式(I)化合物来改善精子受精活性，特别是增加精子运动能力的过程。本发明还涉及在不孕症和辅助生殖技术（ART）中使用式(I)化合物的方法，以及用于储存和/或运输精子的介质，其中包括所述P13K抑制剂。
• Azolidinone-vinyl fused-benzene derivatives
  申请人：Rueckle Thomas

  公开号：US20060122176A1

  公开（公告）日：2006-06-08

  The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R 1 , R 2 and n are as described in the description.

  本发明涉及公式（I）的噻唑烷二酮-乙烯基融合苯衍生物，用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、细菌或病毒感染、肾脏疾病、血小板聚集、癌症、移植排斥或肺损伤。公式（I）中，A，X，Y，Z，R1，R2和n如说明书中所述。
• Use of compounds for increasing spermatozoa motility
  申请人：De Luca Giampiero

  公开号：US20050222225A1

  公开（公告）日：2005-10-06

  The invention relates to a process for the improvement of spermatozoa fertilization activity, in particular for the increase of spermatozoa motility, by using a compound of formula (I). The invention further relates to uses and methods of compounds of formula (I) in infertility and assisted reproduction techniques (ART) as well as to a medium for storage and/or transportation of spermatozoa comprising said P13K inhibitors.

  本发明涉及一种使用式(I)化合物改善精子受精活性的方法，特别是增加精子运动性的方法。本发明还涉及式(I)化合物在不孕症和辅助生殖技术（ART）中的用途和方法，以及一种包含所述P13K抑制剂的精子储存和/或运输介质。
• AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES
  申请人：RUECKLE Thomas

  公开号：US20090306069A1

  公开（公告）日：2009-12-10

  The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. wherein A, X, Y, Z, R 1 , R 2 and n are as described in the description.

  本发明涉及式（I）的噁唑烷二酮-乙烯基融合苯衍生物，用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、细菌或病毒感染、肾脏疾病、血小板聚集、癌症、移植排斥或肺损伤。其中A、X、Y、Z、R1、R2和n如描述所述。