J2Qml6zst8 | 504397-20-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: J2Qml6zst8
• 英文别名: 4-[2-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]ethylamino]-1H-pyridazin-6-one
• CAS: 504397-20-0
• 化学式: C₁₈H₂₃N₅O₃
• 分子量: 357.4
• InChiKey: XGVHQXGZCSWXEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  78.4
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] SUBSTITUTED ALKYL-PYRIDAZINONES FOR THE TREATMENT OF MEMORY AND LEARNING MALFUNCTIONS<br/>[FR] ALKYLE-PYRIDAZINONES SUBSTITUES POUR LE TRAITEMENT DE DYSFONCTIONNEMENTS DE LA MEMOIRE ET DE L'APPRENTISSAGE
  申请人：EGYT GYOGYSZERVEGYESZETI GYAR

  公开号：WO2004043465A1

  公开（公告）日：2004-05-27

  The compounds of the general Formula I, wherein R1 stands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, R2 is hydrogen or lower alkyl; n is 1, 2 or 3; R3 is hydrogen, lower alkyl or aryl-lower alkyl; Z is -0-; or R3 and Z together with the intermediate atoms form a piperazino ring; Q and W independently from each other stands for -CH= or -N=; and R4, R5 and R6 can be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or R4 and R5 together form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.

  通式I的化合物，其中R1代表氢或低碳基；符号X和Y中的一个代表氢或卤素，另一个代表通式II的基团，其中R2代表氢或低碳基；n为1、2或3；R3代表氢、低碳基或芳基-低碳基；Z为-0-；或者R3和Z与中间原子一起形成哌嗪环；Q和W独立地代表-CH=或-N=；R4、R5和R6可以相同也可以不同，代表氢、卤素、三氟甲基或低烷氧基；或者R4和R5一起形成乙二氧基基团。这些化合物及其药学上可接受的盐可以用于治疗或预防记忆失灵和/或认知衰退或预防学习能力下降。
• [EN] SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME<br/>[FR] DERIVES SUBSTITUES D'ALKYLAMINOPYRIDAZINONE, PROCEDES DE PREPARATION ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
  申请人：EGYT GYOGYSZERVEGYESZETI GYAR

  公开号：WO2003027097A1

  公开（公告）日：2003-04-03

  The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.

  本发明涉及一种新的取代烷基氨基吡嗪酮衍生物，其通式为（I），其中R1为氢或具有1-4个碳原子的烷基；X和Y中的一个代表氢或卤素，另一个代表通式（II）的基团，R2为氢或具有1-4个碳原子的烷基；n为1、2或3；R3代表氢、具有1-4个碳原子的烷基或芳基-(C1-4烷基)；Z代表氧；或R3和Z与它们之间放置的基团一起形成哌嗪环；R4代表氢、卤素、三氟甲基或具有1-4个碳原子的烷氧基；以及其药学上可接受的酸加盐。本发明化合物在治疗抗焦虑症和认知障碍方面有用。
• Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
  申请人：——

  公开号：US20040242873A1

  公开（公告）日：2004-12-02

  The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R 1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R 2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R 3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C 1-4 alkyl); Z stands for oxygen; or R 3 and Z together with the groups placed between them form a piperazine ring; and R 4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders. 1

  本发明涉及通式（I）的新取代烷基氨基哒嗪酮衍生物（其中 R 1 是氢或具有 1-4 个碳原子的烷基；X 和 Y 中的一个代表氢或卤素，另一个代表通式（II）的基团，R 2 是氢或具有 1-4 个碳原子的烷基；n 是 1、2 或 3；R 3 代表氢、具有 1-4 个碳原子的烷基或芳基-(C 1-4 烷基）；Z 代表氧；或 R 3 和 Z 与它们之间的基团一起构成一个哌嗪环；以及 R 4 代表氢、卤素、三氟甲基或具有 1-4 个碳原子的烷氧基）及其药学上可接受的酸加成盐。本发明化合物可用于治疗抗焦虑症状和认知障碍。 1
• Substituted alkyl-pyridazinones for the treatment of memory and learning malfunctions
  申请人：Levay Gyorgy

  公开号：US20060211703A1

  公开（公告）日：2006-09-21

  The compounds of the general Formula I, wherein R 1 stands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, R 2 is hydrogen or lower alkyl; n is 1, 2 or 3; R 3 is hydrogen, lower alkyl or aryl-lower alkyl; Z is -0-; or R 3 and Z together with the intermediate atoms form piperazino ring; Q and W independently from each other stands for —CH═ or —N═; and R 4 , R 5 and R 6 can be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or R 4 and R 5 together form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.

  通式 I 的化合物，其中 R 1 代表氢或低级烷基；符号 X 和 Y 中的一个代表氢或卤素，另一个代表通式 II 中的基团，R 2 是氢或低级烷基；n 是 1、2 或 3；R 3 是氢、低级烷基或芳基-低级烷基；Z 是-0-；或 R 3 和 Z 与中间原子一起形成哌嗪环；Q 和 W 各自代表 -CH═ 或 -N═；以及 R 4 , R 5 和 R 6 可以相同或不同，代表氢、卤素、三氟甲基或低级烷氧基；或 R 4 和 R 5 及其药学上可接受的盐类可用于治疗或预防记忆障碍和/或认知能力下降或预防学习能力下降。
• SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Egis Gyogyszergyar Rt.

  公开号：EP1430047A1

  公开（公告）日：2004-06-23