1-[4-[2-Amino-5-(4-methylphenyl)sulfanylpyrimidin-4-yl]piperazin-1-yl]ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[4-[2-Amino-5-(4-methylphenyl)sulfanylpyrimidin-4-yl]piperazin-1-yl]ethanone
• 化学式: C₁₇H₂₁N₅OS
• 分子量: 343.4
• InChiKey: YXMDCEKZYRWICF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES
  申请人：Krenitsky Pharmaceutical Inc

  公开号：EP1165522A1

  公开（公告）日：2002-01-02
• [EN] NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES<br/>[FR] THIOPYRIMIDINES NEUROTROPHIQUES SUBSTITUES
  申请人：KRENITSKY PHARMACEUTICALS INC

  公开号：WO2000059893A1

  公开（公告）日：2000-10-12

  The present invention relates to a series of substituted thiopyrimidines, to pharmaceutical compositions which contain them, to methods for their preparation and to their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral systems.