2-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-2-methyl-1-pyrrolidin-1-ylpropan-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-2-methyl-1-pyrrolidin-1-ylpropan-1-one
• 化学式: C₁₈H₂₅Cl₂N₃O
• 分子量: 370.3
• InChiKey: YSHNTVHGQFASEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  26.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PIPERIDINE AND PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM
  申请人：ELI LILLY AND COMPANY LIMITED

  公开号：EP1104413A2

  公开（公告）日：2001-06-06
• [EN] PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSES PHARMACEUTIQUES
  申请人：LILLY CO ELI

  公开号：WO2000008006A2

  公开（公告）日：2000-02-17

  A pharmaceutical composition comprising a compound of formula (I), or a pharmaceutically-acceptable salt or ester thereof in which X, R?1, R2, R3, R4, R5 and R6¿ have the meanings given in the specification, is useful in the treatment of diseases of the central nervous system. The invention further relates to a compound of formula (I) or a pharmaceutically-acceptable salt or ester thereof useful in the treatment of diseases of the central nervous system.