4-[4-(5-butylpyrazin-2-yl)piperazin-1-yl]sulfonyl-N-hydroxyoxane-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[4-(5-butylpyrazin-2-yl)piperazin-1-yl]sulfonyl-N-hydroxyoxane-4-carboxamide
• 化学式: C₁₈H₂₉N₅O₅S
• 分子量: 427.5
• InChiKey: DCBIUCASZMNWII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS<br/>[FR] ACIDES HYDROXAMIQUES DE PIPERIDINYL- ET DE PIPERAZINYL-SULFONYLMETHYLE ET LEUR UTILISATION COMME INHIBITEURS DE PROTEASE
  申请人：PHARMACIA CORP

  公开号：WO2005042521A2

  公开（公告）日：2005-05-12

  This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to formula (I); (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.