4-(4-benzylpiperazin-1-yl)-1H-indole-2,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-benzylpiperazin-1-yl)-1H-indole-2,3-dione
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.4
• InChiKey: MODMPAQDAMWBEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Thiadiazole compounds and methods of use thereof
  申请人：Bursavich Matthew G.

  公开号：US20080125469A1

  公开（公告）日：2008-05-29

  The present invention relates to Thiadiazole Compounds; compositions comprising an effective dose of a Thiadiazole Compound; and methods treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, cancer, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of a Thiadiazole Compound to a mammal in need thereof.

  本发明涉及噻二唑化合物；包含有效剂量噻二唑化合物的组合物；以及治疗或预防金属蛋白酶相关疾病的方法，例如关节炎、骨关节炎、癌症、类风湿性关节炎、哮喘、慢性阻塞性肺病、动脉粥样硬化、老年性黄斑变性、心肌梗死、角膜溃疡、眼表疾病、肝炎、主动脉瘤、肌腱炎、中枢神经系统疾病、异常伤口愈合、血管生成、再狭窄、肝硬化、多发性硬化、肾小球肾炎、移植物抗宿主病、糖尿病、炎症性肠病、休克、椎间盘退行性变、中风、骨质疏松症或牙周疾病，或包括向需要的哺乳动物施用有效剂量噻二唑化合物。
• Piperazinyl-isatins
  申请人：Wyeth

  公开号：US20030013722A1

  公开（公告）日：2003-01-16

  This invention provides compounds of formula VI 1 wherein Y is hydrogen, methyl, methoxy, methylthio or trifluoromethyl; R is hydrogen, C 1-3 alkyl or (CH 2 ) n Ar; n is 0, 1 or 2; and Ar is phenyl or methoxyphenyl, or a pharmaceutically acceptable salt thereof. These compounds are selective dopamine autoreceptor agonists useful in treating disease states involving hyperactivity of dopamine systems. The invention also comprises intermediate compounds, compositions and methods related to the compounds of formula VI.

  这项发明提供了公式VI1的化合物，其中Y是氢、甲基、甲氧基、甲硫基或三氟甲基；R是氢、C1-3烷基或(CH2)nAr；n为0、1或2；Ar是苯基或甲氧基苯基，或其药用可接受的盐。这些化合物是选择性多巴胺自主受体激动剂，可用于治疗涉及多巴胺系统过度活跃的疾病状态。该发明还涉及公式VI化合物的中间体化合物、组合物和方法。
• THIADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Wyeth

  公开号：EP2032584A2

  公开（公告）日：2009-03-11
• US6743796B2
  申请人：——

  公开号：US6743796B2

  公开（公告）日：2004-06-01
• [EN] PIPERAZINYL-ISATINS<br/>[FR] PIPERAZINYL-ISATINES
  申请人：WYETH CORP

  公开号：WO2002090327A1

  公开（公告）日：2002-11-14

  This invention provides compounds of formula VI wherein Y is hydrogen, methyl, methoxy, methylthio or trifluoromethyl; R is hydrogen C1-3alkyl or (CH2)nAr; n is O, 1 or 2; and Ar is phenyl or methoxyphenyl, or a pharmaceutically acceptable salt thereof. These compounds are selective dopamine autoreceptor agonists useful in treating disease states involving hyperactivity of dopamine systems. The invention also comprises intermediate compounds, compositions and methods related to the compounds of formula VI.