1,1'-(癸烷-1,10-二基)二(咪唑并啉-2,4-二酮) | 88992-94-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1,1'-(癸烷-1,10-二基)二(咪唑并啉-2,4-二酮)
• 中文别名: N-[2-(1-哌嗪基)乙基]-2-丙烯酰胺
• 英文名称: N-[2-(Piperazin-1-yl)ethyl]prop-2-enamide
• 英文别名: N-(2-piperazin-1-ylethyl)prop-2-enamide
• CAS: 88992-94-3
• 化学式: C₉H₁₇N₃O
• 分子量: 183.25
• InChiKey: YHISAQJGKPTPHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PIPERAZINOTRIAZINES AS PI3K INHIBITORS FOR USE IN THE TREATMENT ANTIPROLIFERATIVE DISORDERS
  申请人：Cmiljanovic Vladimir

  公开号：US20130040912A1

  公开（公告）日：2013-02-14

  The invention relates to compounds of formula (I) R1 is methyl, n-hexyl, aminoethyl, methylaminoethyl, ethylaminoethyl, dimethylaminoethyl, acryloylaminoethyl, methacryloylaminoethyl, methoxyethyl, ethoxyethyl, d-C4-alkyl-sulfonyl, acryloyl, or methacryloyl; or R1 is aminoethyl, acryloyl or acryloylaminoethyl carrying a linker and a tag, and R2 and R3, independently of each other, are hydrogen or CrC4-alkyl, or R2 and R3 together form a methylene or an ethylene bridge; and tautomers, solvates and pharmaceutically acceptable salts thereof. These compounds are effective in preventing or treating a disease or disorder modulated by PI3 kinases and/or mTOR, in particular treating a hyperproliferative disorder.

  该发明涉及以下式(I)的化合物：R1为甲基、正己基、氨乙基、甲基氨基乙基、乙基氨基乙基、二甲基氨基乙基、丙烯酰胺基乙基、甲基丙烯酰胺基乙基、甲氧基乙基、乙氧基乙基、d-C4-烷基磺酰基、丙烯酰基或甲基丙烯酰基；或者R1为氨乙基、丙烯酰基或丙烯酰胺基乙基，携带一个连接基和一个标签，而R2和R3，彼此独立，为氢或CrC4-烷基，或者R2和R3一起形成一个亚甲基或一个乙烯基桥；以及它们的互变异构体、溶剂合物和药学上可接受的盐。这些化合物在预防或治疗由PI3激酶和/或mTOR调节的疾病或紊乱中具有有效作用，特别是在治疗过度增殖性紊乱方面。
• POLYMER COMPOSITIONS AND PROCESSES FOR MAKING AND USING SAME
  申请人：CHEVRON PHILLIPS CHEMICAL COMPANY LP

  公开号：EP1940917A2

  公开（公告）日：2008-07-09
• POLYMER COMPOSITIONS AND METHODS OF MAKING AND USING SAME
  申请人：Polymeright Inc.

  公开号：EP2448990A1

  公开（公告）日：2012-05-09
• METHOD OF THIOPHENOL REMOVAL FROM POLY(ARYLENE SULFIDE) POLYMER COMPOSITIONS
  申请人：SOLVAY SA

  公开号：EP3063210A2

  公开（公告）日：2016-09-07
• Polymer Compositions and Methods of Making and Using Same
  申请人：RAPPOPORT Leonid

  公开号：US20110152492A1

  公开（公告）日：2011-06-23

  A composition comprising a reaction product of reactants comprising (a) a compound comprising (i) a polysulfide moiety and (ii) an oxygen atom in a β-position to a sulfur link having the formula: where each R is independently selected from H or a C 1 to C 20 organyl group, R′ is independently selected from a C 1 to C 20 organyl group, R′″ is independently selected from H or a C 1 to C 20 organyl group, and x has an average of greater than 2, (b) a compound comprising a nucleophilic moiety; and (c) a compound comprising a moiety reactive to active hydrogen.