1-{[2-(2-fluorophenyl)imidazol-5-yl]methyl}-4-(2-quinolyl)piperazine oxalate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-{[2-(2-fluorophenyl)imidazol-5-yl]methyl}-4-(2-quinolyl)piperazine oxalate
• 英文别名: 2-[4-[[2-(2-fluorophenyl)-1H-imidazol-5-yl]methyl]piperazin-1-yl]quinoline;oxalic acid
• 化学式: C₂H₂O₄*C₂₃H₂₂FN₅
• 分子量: 477.495
• InChiKey: SRJJRURFAXKQHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.24
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• US6166205A
  申请人：——

  公开号：US6166205A

  公开（公告）日：2000-12-26
• [EN] 2-ARYL-4-(1-[4-HETEROARYL]PIPERAZIN-1-YL) METHYLIMIDAZOLES: DOPAMINE D4 RECEPTOR SUBTYPE LIGANDS<br/>[FR] 2-ARYL-4-[4-HETEROARYL]PIPERAZIN-1-YL METHYLIMIDAZOLES: LIGANDS POUR LE SOUS-TYPE DE RECEPTEUR D4 DE LA DOPAMINE
  申请人：NEUROGEN CORP

  公开号：WO2000012500A2

  公开（公告）日：2000-03-09

  Disclosed are compounds of formula: (I) or the pharmaceutically acceptable acid addition salts thereof wherein Ra represents (II) where X, Y and Z are the same or different and represent CH or nitrogen; R1, R2, R3 and R4 independently represent organic or inorganic groups: and R5 is hydrogen, C1-C6 alkyl or halogen, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behaviour, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.