1,2-二噻烷-3,6-二甲酸 | 6623-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二噻烷
• 中文名称: 1,2-二噻烷-3,6-二甲酸
• 英文名称: rac. 1.2-Dithian-dicarbonsaeure-(3.6)
• 英文别名: 3.6-Dicarboxy-1.2-dithia-cyclohexan；1.2-Dithian-3.6-dicarbonsaeure；[1,2]dithiane-3,6-dicarboxylic acid；Dithiane-3,6-dicarboxylic acid
• CAS: 6623-09-2
• 化学式: C₆H₈O₄S₂
• 分子量: 208.259
• InChiKey: NQRRVGBUZRSXRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2934999090

文献信息

• Tethering cysteine residues using cyclic disulfides
  申请人：Brandeis University

  公开号：US10711261B2

  公开（公告）日：2020-07-14

  Described herein are compounds and methods for tethering proteins. For example, dimers of Protein X listed in Table 1 are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization and can be used to treat neurodegenerative diseases (such as, for example, Parkinson's Disease, ALS, Alzheimer's Disease, Huntington's Disease, Epilepsy, Frontotemporal Dementia, and/or DMD), cancer, autoimmune disease, and/or Celiac disease.

  本文描述了用于系链蛋白质的化合物和方法。例如，描述了表 1 所列蛋白质 X 的二聚体，其中二聚体是通过环状二硫连接体将第一单体上的半胱氨酸与第二单体上的半胱氨酸共价键合而形成的。共价连接的二聚体具有更高的稳定性，可用于治疗神经退行性疾病（例如帕金森病、渐冻人症、阿尔茨海默病、亨廷顿氏病、癫痫、额颞叶痴呆和/或 DMD）、癌症、自身免疫性疾病和/或乳糜泻。
• EP2920196B1
  申请人：——

  公开号：EP2920196B1

  公开（公告）日：2021-03-31
• Tethering Cysteine Residues Using Cyclic Disulfides
  申请人：BRANDEIS UNIVERSITY

  公开号：US20150284478A1

  公开（公告）日：2015-10-08

  Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.
• TETHERING CYSTEINE RESIDUES USING CYCLIC DISULFIDES
  申请人：Brandeis University

  公开号：US20160333336A1

  公开（公告）日：2016-11-17

  Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.
• US3954685A
  申请人：——

  公开号：US3954685A

  公开（公告）日：1976-05-04