1,3-苯二羧酸,5-4-(7-氨基-1-羟基-3-硫代-2-萘基)偶氮-6-硫代-1-萘基偶氮-,盐四铵 | 91015-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1,3-苯二羧酸,5-4-(7-氨基-1-羟基-3-硫代-2-萘基)偶氮-6-硫代-1-萘基偶氮-,盐四铵
• 中文别名: 2-己基哌嗪
• 英文名称: 2-Hexyl-piperazin
• 英文别名: 2-hexyl-piperazine；2-Hexylpiperazine
• CAS: 91015-24-6
• 化学式: C₁₀H₂₂N₂
• 分子量: 170.298
• InChiKey: YLGXUGLWJZZSEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3-苯二羧酸,5-4-(7-氨基-1-羟基-3-硫代-2-萘基)偶氮-6-硫代-1-萘基偶氮-,盐四铵 在 盐酸 、 三乙胺 作用下， 以 二氯甲烷 、 水 、 丙酮 为溶剂， 反应 6.0h， 生成 2-Hexyl-1-(toluene-4-sulfonyl)-piperazine; hydrochloride
  参考文献：
  名称：

  血小板活化因子（PAF）中的构效关系。11从PAF拮抗作用到磷脂酶A（2）抑制：1-芳基磺酰胺基-2-烷基哌嗪的合成与结构活性关系。

  摘要：

  1-苄基-2-烷基哌嗪是I和II组分泌的PLA（2）s的强抑制剂。通过用磺酰胺取代酰胺官能团并通过在苯磺酰基部分的对位引入电子给体取代基，可以提高其活性。哌嗪环的一个碳原子上的位置或该碳原子的绝对构型都不会影响对PLA（2）的一个或另一个基团的亲和力，但亲脂性对于这些系列仍然是必不可少的参数。此外，结构活性关系允许这些哌嗪衍生物与PLA（2）s催化位点相互作用的新假设。

  DOI：

  10.1016/s0223-5234(01)01274-0

文献信息

• Isoquinolinesulfonyl derivatives and process for the preparation thereof
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0061673A1

  公开（公告）日：1982-10-06

  A 5-isoquinolinesulfonyl derivative of Formula (I): wherein f is zero or one; m and n each is an integer of one to nine; m+n is an integer of at least one; R1 is a hydrogen atom, a C1-10 alkyl group, a C5-6cycloalkyl group or an aryl group; or R2 and R3 each is a hydrogen atom, a C1-10 alkyl group, a C5-6 cycloalkyl group, an aryl group or an aralkyl group; R2 and R3 are C1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; or the group is a group wherein R4 and Rs each is a hydrogen atom, a C1-10 alkyl group, an aryl group or an aralkyl group and R6 is a hydrogen atom, a C1-10 alkyl group, an aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a group wherein R, is a C1-8 alkyl group, and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.

  式(I)的 5-异喹啉磺酰基衍生物： 其中 f 为零或一 m 和 n 均为一至九的整数 m+n 至少为 1 的整数； R1 是氢原子、C1-10 烷基、C5-6 环烷基或芳基；或 R2 和 R3 各为氢原子、C1-10 烷基、C5-6 环烷基、芳基或芳烷基； R2 和 R3 为 C1-6 烯基，直接或通过氧原子连接，与相邻的氮原子形成 5-7 元杂环；或 基团为 其中 R4 和 Rs 分别为氢原子、C1-10 烷基、芳基或芳烷基，R6 为氢原子、C1-10 烷基、芳基、芳烷基、苯甲酰基、肉桂酰基、肉桂酰基、呋喃基或 其中 R 是 C1-8 烷基的基团及其药学上可接受的盐；以及其制备方法。本发明的化合物对血管平滑肌具有松弛作用，可用作血管扩张剂和降压剂。
• PROCESS FOR PRODUCING FLEXIBLE POLYURETHANE FOAM
  申请人：ASAHI GLASS COMPANY LTD.

  公开号：EP1273605A1

  公开（公告）日：2003-01-08

  A process for producing a flexible polyurethane foam satisfying low resilience, high vibration absorption and high durability, is presented. A mixture comprising from 95 to 50 mass% of a polyoxyalkylene polyol produced by means of an alkali metal catalyst and from 5 to 50 mass% of a polyoxyalkylene polyol produced by means of a double metal cyanide complex catalyst, is reacted with a polyisocyanate compound in the presence of a catalyst and a blowing agent, to produce a flexible polyurethane foam having a resonance frequency of at most 3.7 Hz, a resonance ratio of at most 3.5 and an impact resilience of at most 70%.

  本发明提出了一种生产满足低回弹性、高吸振性和高耐久性要求的软质聚氨酯泡沫塑料的工艺。在催化剂和发泡剂存在的情况下，一种由 95 至 50 质量％的通过碱金属催化剂生产的聚氧亚烷基多元醇和 5 至 50 质量％的通过双金属氰化物络合催化剂生产的聚氧亚烷基多元醇组成的混合物与一种多异氰酸酯化合物反应，生产出一种共振频率不超过 3.7 赫兹、共振比不超过 3.5 和冲击回弹率不超过 70％的软质聚氨酯泡沫塑料。
• METHOD FOR PRODUCING SOFT POLYURETHANE FOAM
  申请人：Asahi Glass Company, Limited

  公开号：EP2067804A1

  公开（公告）日：2009-06-10

  To provide a process for producing a flexible polyurethane foam, which can suitably form a flexible polyurethane foam having a good cushioning characteristic by using a raw material derived from a natural fat/oil. The process comprises a step of reacting a polyoxyalkylene polyol (A) containing the first polyoxyalkylene polyol (A1) obtained by ring-opening polymerization of an alkylene oxide (c) with an initiator (b) in the presence of a polymerization catalyst (a), with a polyisocyanate compound (B) in the presence of a catalyst (C) and a blowing agent (D). The polymerization catalyst (a) is at least one member selected from the group consisting of a coordination anionic polymerization catalyst and a cationic polymerization catalyst, and the initiator (b) is a polyol derived from a natural fat/oil, which is obtained by providing a natural fat/oil with hydroxyl groups through a chemical reaction, and has a hydroxyl value of from 20 to 250 mgKOH/g and a ratio of the mass average molecular weight to the number average molecular weight calculated as polystyrene, (Mw/Mn), of at least 1.2.

  提供一种生产软质聚氨酯泡沫塑料的工艺，该工艺通过使用从天然脂肪/油中提取的原料，可以适当地形成具有良好缓冲特性的软质聚氨酯泡沫塑料。 该工艺包括以下步骤：在催化剂（C）和发泡剂（D）存在的情况下，将含有通过环氧烷（c）与引发剂（b）开环聚合得到的第一种聚氧亚烷基多元醇（A1）的聚氧亚烷基多元醇（A）与多异氰酸酯化合物（B）反应。聚合催化剂(a)至少是从配位阴离子聚合催化剂和阳离子聚合催化剂组成的组中选出的一个成员，而引发剂(b)是从天然脂肪/油中提取的多元醇，该多元醇是通过化学反应使天然脂肪/油具有羟基而得到的，其羟值为 20 至 250 mgKOH/g，质量平均分子量与按聚苯乙烯计算的数量平均分子量之比(Mw/Mn)至少为 1.2。
• METHOD FOR PRODUCTION OF POLYMER-DISPERSED POLYOL, AND METHOD FOR PRODUCTION OF FLEXIBLE POLYURETHANE FOAM
  申请人：Asahi Glass Company, Limited

  公开号：EP2161289A1

  公开（公告）日：2010-03-10

  To provide a process for producing a flexible polyurethane foam having a higher biomass degree than a conventional flexible polyurethane foam and excellent in foam physical properties and its appearance. A polymer-dispersed polyol obtained by polymerizing a vinyl monomer in the presence of the following polyol (a1) derived from a natural fat/oil and/or the following polyoxyalkylene polyol (a2) is used: Polyol (a1) derived from a natural fat/oil: a polyol derived from a natural fat/oil, which is obtained by providing a natural fat/oil with hydroxy groups by chemical reaction, and which has a hydroxy value of from 20 to 250 mgKOH/g and a molecular weight distribution of at least 1.2; Polyoxyalkylene polyol (a2): a polyoxyalkylene polyol which is produced by ring-opening polymerization of an alkylene oxide (c) with the polyol (a1) derived from a natural fat/oil in the presence of at least one polymerization catalyst (b) selected from the group consisting of a coordination anionic polymerization catalyst and a cationic polymerization catalyst.

  提供一种生产软质聚氨酯泡沫塑料的工艺，该泡沫塑料的生物质含量高于传统的软质聚氨酯泡沫塑料，而且泡沫塑料的物理性能和外观极佳。 使用一种聚合物分散多元醇，该多元醇是通过乙烯基单体在以下多元醇（a1）和/或以下聚氧亚烷基多元醇（a2）存在下进行聚合而得到的：由天然脂肪/油衍生的多元醇（a1）：由天然脂肪/油衍生的多元醇，通过化学反应使天然 脂肪/油具有羟基，其羟值为 20 至 250 mgKOH/g，分子量分布至少为 1。2; 聚氧亚烷基多元醇（a2）：一种聚氧亚烷基多元醇，由环氧亚烷基（c）与来自天然脂 肪/油的多元醇（a1）在至少一种聚合催化剂（b）的存在下开环聚合而成，该催化剂选 自配位阴离子聚合催化剂和阳离子聚合催化剂组成的组。
• POLYMER-DISPERSED POLYOL AND METHOD FOR MANUFACTURING A SOFT POLYURETHANE FOAM
  申请人：Asahi Glass Company, Limited

  公开号：EP2471826A1

  公开（公告）日：2012-07-04

  To provide a polymer-dispersed polyol made by using materials derived from a natural fat/oil, which has a low viscosity, without lowering the biomass degree and without impairing the performance of a flexible polyurethane foam to be obtained. Further, to provide a process for producing a flexible polyurethane foam using the polymer-dispersed polyol. A polymer-dispersed polyol, comprising polymer particles dispersed in a matrix containing a polyol (a1) derived from a natural fat/oil and an epoxidized natural fat/oil (x). And, a process for producing a flexible polyurethane foam, which comprises reacting a polyol containing the above polymer-dispersed polyol and a polyisocyanate compound in the presence of a catalyst and a blowing agent.

  提供一种聚合物分散多元醇，该多元醇使用从天然脂肪/油中提取的材料制成，具有低粘度，不会降低生物量，也不会损害所获得的软质聚氨酯泡沫的性能。进一步，提供一种使用聚合物分散多元醇生产软质聚氨酯泡沫塑料的工艺。 一种聚合物分散多元醇，包括分散在含有多元醇（a1）的基质中的聚合物颗粒，多元醇（a1）来源于天然脂肪/油和环氧化天然脂肪/油（x）。一种生产软质聚氨酯泡沫塑料的工艺，包括在催化剂和发泡剂存在下，使含有上述聚合物分散多元醇的多元醇和多异氰酸酯化合物发生反应。